228418-97-1

Upstream product

• 228419-04-3 4-Cyclohexyl-3-methyl-4-oxo-3-phenylbutyraldehyde 
• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 823-76-7 Cyclohexyl methyl ketone 
• 4354-48-7 2-cyclohexyl-2-oxoacetaldehyde 
• 104-55-2 3-phenyl-propenal 
• 228418-96-0 2-(2'-cyclohexanecarbonyl-2'-phenyl)ethyl-1,3-dioxolane 
• 1347677-19-3 4-Cyclohexyl-4-oxo-3-phenyl-butyraldehyde Diethyl Acetal 

Downstream Products

• 228418-68-6 1-(2-methoxyphenyl)-4-[3-(cyclohexanecarbonyl)-3-(phenyl)propyl]piperazine 

Relevant academic research and scientific papers

Stereocontrolled Synthesis of 1,4-Dicarbonyl Compounds by Photochemical Organocatalytic Acyl Radical Addition to Enals

We report a visible-light-mediated organocatalytic strategy for the enantioselective acyl radical conjugate addition to enals, leading to valuable 1,4-dicarbonyl compounds. The process capitalizes upon the excited-state reactivity of 4-acyl-1,4-dihydropyridines that, upon visible-light absorption, can trigger the generation of acyl radicals. By means of a chiral amine catalyst, iminium ion activation of enals ensures a stereoselective radical trap. We also demonstrate how the combination of this acylation process with a second catalyst-controlled bond-forming event allows to selectively access the full matrix of all possible stereoisomers of the resulting 2,3-substituted 1,4-dicarbonyl products.

Arylpiperazines having activity at the serotonin 1A receptor

A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

N,N-DISUBSTITUTED DIAZOCYCLOALKANES

N,N-Disubstituted diazocycloalkanes of the formula I (R1=halogen, R2=(C3-C 8)-cycloalkyl, R3=(C1-C4)-alkoxy or (C 1-C4)-haloalkoxy group, m is 1 or 2 and n is 1 or 2, have affinity for serotonergic receptors. These compounds and their enantiomers, diaster

N,N-DISUBSTITUTED DIAZOCYCLOALKANES USEFUL FOR THE TREATMENT OF CNS DISORDERS DUE TO SEROTONERGIC DYSFUNCTION

N,N-Disubstituted diazocycloalkanes of the formula (I): (R1 = halogen, R2 = (C3-C8)-cycloalkyl, R3 = (C1-C4)-alkoxy or (C1-C4)-haloalkoxy group, m is 1 or 2, n is 1 or 2) have affinity for serotoninergic receptors. These compounds and their enantiomers, diastereoisomers, N-oxides, polymorphs, solvates and pharmaceutically acceptable salts are useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptor. 1,4-Disubstituted-piperazines (n = 1) are preferred. R1 is preferably F in the 2-position, R2 is preferably cyclohexyl, and R3 is preferably a methoxy or 2,2,2-trifluoroethyl group. Preferably, m = 1.

Arylpiperazines having activity at the serotonin 1A receptor

A series of aryl piperazine compounds of the formula: or the pharmaceutically acceptable salts thereof, are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1Areceptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.