2285-28-1

Usage

Uses

Used in Organic Synthesis:
2,4'-Difluorobiphenyl is utilized as a building block for the synthesis of other organic compounds, leveraging its unique structure and properties to create a variety of chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,4'-Difluorobiphenyl serves as a research chemical, contributing to the development of new drugs by providing a foundation for the exploration of novel molecular structures and their potential therapeutic effects.
Used in Agricultural Research:
Similarly, in the agricultural sector, 2,4'-Difluorobiphenyl is employed as a research chemical, aiding in the discovery and design of new agrochemicals with improved efficacy and selectivity, by offering a versatile starting point for the synthesis of bioactive molecules.

Upstream product

• 462-06-6 fluorobenzene 

Relevant academic research and scientific papers

PALLADIUM(II)-CATALYZED OXIDATIVE COUPLING OF ARENES BY THALLIUM(III)

Oxidation of benzenes with electron-donating and moderate electron-withdrawing substituents by thallium(III) trifluoroacetate in the presence of catalytic amounts of palladium(II) acetate affords biaryls in good yields.The GLC study of the isomer distribution has shown that 4,4'-biaryls are the major products.Thus, the 4,4'-biaryls can be easily isolated either by recrystallization or column chromatography.The competitive experiments and kinetic study using arenes and arylthallium derivatives as starting materials as well as quenching experiments have demonstrated the first step of the reaction to be fast thallation of arene to form arylthallium intermediate ArTl(OOCCF3)2.The latter undergoes the rate-determining transmetallation step reacting with monomeric complex Pd(OAc)2, which is formed upon depolymerization of trimer Pd3(OAc)6.Subsequent fast decomposition of arylpalladium species gives the final reaction products.The thallation of arene and substitution of TlIII for PdII in ArTl(OOCCF3)2 are characterized by the slopes of Hammet plots of -5.6 (?+) and -3.0 (?), respectively.