228556-30-7Relevant academic research and scientific papers
Taxoid C-ring building blocks from Hajos-Parrish ketone. Practical synthesis of an enantiomerically pure taxoid ABC ring system
Martin Hernando, Jose Ignacio,Quilez Del Moral, Jose,Del Rosario Rico Ferreira, Maria,Candela Lena, Jose Ignacio,Arseniyadis, Simeon
, p. 783 - 797 (2007/10/03)
A synthesis and characterization of conveniently functionalized taxoid C-ring building blocks to be used in an A+C approach is presented. Subsequently, a four-step entry to the tricyclic taxoid ABC skeleton, which allows for a high degree of convergency and is highlighted by a stannylene- mediated coupling to link the left- and right-half moieties, followed by an intramolecular aldol reaction to effect the B-ring closure, is described.
An expedient synthesis of a conveniently functionalized optically homogeneous taxoid ABC ring system
Arseniyadis, Simeon,Martin Hernando, Jose Ignacio,Quilez Del Moral, Jose,Rico Ferreira, Maria Del Rosario,Birlirakis, Nicolas,Potier, Pierre
, p. 9011 - 9014 (2007/10/03)
We present a four-step A+C route to an optically pure taxoid ABC framework 3a containing suitable functionalities for further elaboration.
