219136-68-2

Upstream product

• 219136-66-0 3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone 
• 100-39-0 benzyl bromide 
• 155095-85-5 2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-ethanol 
• 219136-91-1 (1S,2S,3S,4S)-3-(2-Benzyloxy-ethyl)-4-tert-butoxy-2-hydroxymethyl-3-methyl-cyclohexanol 
• 219136-58-0 (4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine 
• 219136-60-4 3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanol 

Downstream Products

• 228556-23-8 [(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol 
• 228556-26-1 2-((1S,2S,6S)-6-tert-Butoxy-2-[1,3]dioxolan-2-yl-1-methyl-3-methylene-cyclohexyl)-ethanol 
• 228556-24-9 (1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexanecarbaldehyde 
• 228556-25-0 2-[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-[1,3]dioxolane 
• 228556-30-7 2-[6-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-ethanol 

Relevant academic research and scientific papers

Taxoid C-ring building blocks from Hajos-Parrish ketone. Practical synthesis of an enantiomerically pure taxoid ABC ring system

A synthesis and characterization of conveniently functionalized taxoid C-ring building blocks to be used in an A+C approach is presented. Subsequently, a four-step entry to the tricyclic taxoid ABC skeleton, which allows for a high degree of convergency and is highlighted by a stannylene- mediated coupling to link the left- and right-half moieties, followed by an intramolecular aldol reaction to effect the B-ring closure, is described.

An expedient synthesis of a conveniently functionalized optically homogeneous taxoid ABC ring system

We present a four-step A+C route to an optically pure taxoid ABC framework 3a containing suitable functionalities for further elaboration.