228559-85-1

Usage

Uses

Used in Medicinal Chemistry:
4-(6,7-DiMethoxyquinolin-4-yloxy)-2-MethoxybenzenaMine is used as a research compound for exploring its pharmacological properties and potential therapeutic applications. Its unique structure and chemical properties make it a candidate for further investigation in the development of new drugs.
Used in Drug Development:
In the pharmaceutical industry, 4-(6,7-DiMethoxyquinolin-4-yloxy)-2-MethoxybenzenaMine is utilized as a lead compound in the discovery and optimization of novel therapeutic agents. Its structure may offer insights into the design of new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C18H18N2O4/c1-21-16-8-11(4-5-13(16)19)24-15-6-7-20-14-10-18(23-3)17(22-2)9-12(14)15/h4-10H,19H2,1-3H3

Upstream product

• 228559-87-3 4-(3-fluoro-4-nitrophenoxy)-6,7-dimethoxyquinoline 
• 394-41-2 3-fluoro-4-nitrophenol 
• 35654-56-9 6,7-dimethoxy-4-chloroquinoline 
• 16292-95-8 4-nitro-3-methoxyphenol 

Relevant academic research and scientific papers

Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors

The overexpression of AXL kinase has been described in many types of cancer. Due to its role in proliferation, survival, migration, and resistance, AXL represents a promising target in the treatment of the disease. In this study we present a novel compound family that successfully targets the AXL kinase. Through optimization and detailed SAR studies we developed low nanomolar inhibitors, and after further biological characterization we identified a potent AXL kinase inhibitor with favorable pharmacokinetic profile. The antitumor activity was determined in xenograft models, and the lead compounds reduced the tumor size by 40% with no observed toxicity as well as lung metastasis formation by 66% when compared to vehicle control.

URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS

The present invention provides compounds of Formula I, or pharmaceutically acceptable salt forms thereof, wherein Ra, Rb, Rc, Rd, D, W, R1a, R1b, R1c,Y, R3, X, E and G are as defined herein, methods of treatment and uses thereof.