228579-91-7

Upstream product

• 91229-91-3 tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate 

Downstream Products

• 851544-48-4 (3aS,5R,7aS,9aS)-3-benzyl-4-oxo-decahydro-2-oxa-3,4a-diazacyclopenta[f]azulene-5-carboxylic acid tert-butyl ester 
• 851544-42-8 (3aR,5R,7aR,9aR)-3-benzyl-4-oxo-decahydro-2-oxa-3,4a-diazacyclopenta[f]azulene-5-carboxylic acid tert-butyl ester 
• 914305-11-6 N-9-fluorenylmethoxycarbonyl-trans-5-triphenylmethylthiomethyl-L-proline 
• 914305-16-1 trans-5-triphenylmethylthiomethyl-L-proline 

Relevant academic research and scientific papers

Asymmetric synthesis of L-proline regio- and stereoselectively labelled with deuterium

A synthesis of L-proline where all of the ring methylenes are stereoselectively labelled with deuterium is described. A catalytic deuteration of protected 3,4-dehydro-L-proline using transition metal catalyst followed by RuO4-oxidation gave a [3,4-D2]pyroglutamic acid derivative. A syn-selective deuteration of the aminal derived from the pyroglutamate with Et3SiD-BF3 · OEt2 furnished (2S,3S,4R,5S)-[3,4,5- D3]proline. The present procedure is also applied to the synthesis of the corresponding (2S,3S,4R,5R)-isomer.

MASP INHIBITORY COMPOUNDS AND USES THEREOF

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

INDUCTION OF ALPHA HELIX CONFORMATIONS IN PROTEINS AND PEPTIDES

Substituted tricyclic diproline analogues of the formula (I): wherein the variables are as defined herein. Also disclosed are methods for the production thereof, the use thereof for the induction of an alpha-helix conformation in peptides and/or proteins, pharmaceuticals containing said compounds, methods for the production of a peptide library containing said compounds, and peptide libraries containing said compounds.

C-glycosylation of cyclic N-acyliminium ions with trimethylsilyloxyfuran

C-glycosylation of 2-methoxy-5-alkoxycarbonyl pyrrolidines with trimethylsilyloxyfuran allows us to obtain the corresponding pyrrolidines contigus to a α,β-unsaturated butyrolactone.