228580-18-5Relevant academic research and scientific papers
Efficient synthesis of (R)- and (S)-1-amino-2,2-difluorocyclopropanecarboxylic acid via lipase-catalyzed desymmetrization of prochiral precursors
Kirihara, Masayuki,Kawasaki, Masashi,Takuwa, Tomofumi,Kakuda, Hiroko,Wakikawa, Takahiro,Takeuchi, Yoshio,Kirk, Kenneth L.
, p. 1753 - 1761 (2007/10/03)
The asymmetric syntheses of (+)-(R)-1-amino-2,2-difluorocyclopropane-1-carboxylic acid and its enantiomer have been accomplished. Key reactions in the synthetic design are lipase-catalyzed desymmetrization of a prochiral diol and a prochiral diacetate.
Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid through lipase-catalyzed asymmetric acetylation
Kirihara, Masayuki,Takuwa, Tomofumi,Kawasaki, Masashi,Kakuda, Hiroko,Hirokami, Shun-Ichi,Takahata, Hiroki
, p. 405 - 406 (2007/10/03)
(+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.
