228581-79-1

Basic information

• Product Name: ethyl 2-(2-aminobenzoylamino)-benzoate
• Synonyms: ethyl 2-(2-aminobenzoylamino)-benzoate
• CAS NO: 228581-79-1
• Molecular Weight: 284.315
• Mol File: 228581-79-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-aminobenzoylamino)-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-aminobenzoylamino)-benzoate(228581-79-1)
• EPA Substance Registry System: ethyl 2-(2-aminobenzoylamino)-benzoate(228581-79-1)

Safety Data

• Hazardous Substances Data: 228581-79-1(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 87-25-2 2-ethoxycarbonylaniline 
• 552-16-9 ortho-nitrobenzoic acid 
• 150256-42-1 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)benzoic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 326901-33-1 ethyl 2-(2-nitrobenzoylamino)-benzoate 

Downstream Products

• 612-34-0 N-anthraniloyl-anthranilic acid 
• 228580-60-7 ethyl 2-[[2-(benzylamino)benzoyl]amino]benzoate 
• 89369-45-9 ethyl 2-[2-(methanesulfonylamino)benzoylamino]benzoate 
• 1352126-59-0 ethyl 2-[(2-benzoylamino)benzoylamino]benzoate 
• 1352126-64-7 2-[2-(trimethylacetylamino)benzoylamino]benzoic acid 
• 1352126-65-8 2-[[2-(cyclohexanecarboxylamino)benzoyl]amino]benzoic acid 
• 1352126-66-9 2-{[2-(3-carboxypropanamido)benzene]amido}benzoic acid 
• 228580-61-8 2-[2-(benzylamino)benzoylamino]benzoic acid 
• 1352126-74-9 2-[2-(3-fluorobenzoylamino)-benzoylamino]benzoic acid 
• 1352126-75-0 2-[2-(4-fluorobenzoylamino)-benzoylamino]benzoic acid 
• 10129-16-5 2-[[2-(benzoylamino)benzoyl]amino]-benzoic acid 
• 58426-37-2 2-[2-(acetylamino)benzoylamino]benzoic acid 
• 5832-68-8 2-[2-(methanesulfonylamino)benzoylamino]benzoic acid 
• 35889-75-9 2-({2-[(4-methylbenzene)sulfonamido]benzene}amido)benzoic acid 

Relevant articles and documents

Synthesis of pyrazolopyrimidinones as sildenafil derivatives and sclerotigenin

A series of novel pyrazolo pyrimidinone derivatives (3(a–d), 4(a–d), and 6(a–d)) was synthesized from various pyrazolo amides (2a–d) which are synthesized by the reaction between ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) and various lithium amides. In addition, we also described the synthesis of sclerotigenin drug molecule which has quinazoline moiety from simple 2-nitro benzoic acid with high yields.

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication

2-[2-Benzoylamino)benzoylamino]benzoic acid (1) was previously identified as a potent and nontoxic antiadenoviral compound (Antimicrob. Agents Chemother. 2010, 54, 3871). Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity.