22859-84-3Relevant articles and documents
A Tandem Amino-Cope Rearrangement/Enamine Alkylation Reaction
Allin, Steven M.,Button, Martin A. C.,Shuttleworth, Stephen J.
, p. 725 - 727 (1997)
Thermally induced [3,3]-sigmatropic rearrangement of 3-amino-1,5-diene substrates occurs to give the corresponding enamine products in high yield and with excellent trans:cis enamine selectivity. The enamine produced during the amino-Cope rearrangement has been directly derivatized, representing the first report of a tandem amino-Cope rearrangemenl/enamine alkylation reaction. The potential of this novel synthetic strategy is outlined.