2287-08-3

Upstream product

• 123-75-1 pyrrolidine 
• 2287-09-4 α-Bromo-ω-(2-methoxy-4-nitrophenoxy)propane 
• 19748-66-4 3-pyrrolidin-1-yl-propan-1-ol 
• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 

Downstream Products

• 515879-68-2 3-methoxy-4-(3-(pyrrolidin-1-yl)propoxy)aniline 
• 16089-42-2 3-methoxy-4-pyrrolidin-1-yl-phenylamine 

Relevant academic research and scientific papers

COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF

The present invention relates compounds of Formula (A) as H3R antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of Histamine 3 Receptor (H3R) functions. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to H3R functions in humans.

MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1a, R1b, R1c, Q, A, R3, W, D and R2 are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.