228718-03-4Relevant academic research and scientific papers
Efficient syntheses of 2-(3',5'-difluorophenyl)-3-(4'- methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor
Zhao, Dalian,Feng, Xu,Chen, Cheng-yi,Tillyer, Rich D.,Grabowski, Edward J. J.,Reider, Paul J.,Black, Cameron,Quimet, Nathalie,Prasit, Peppi
, p. 6001 - 6018 (1999)
2-(3',5'-Difluorophenyl)-3-(4'-methylsulfonylphenyl)cyclopent-2-enone (1) displays high selectivity and potency against COX-2. Three efficient syntheses of this diarylcyclopentenone are described. The first approach employs a Suzuki coupling reaction as the key step while the second synthesis features an intramolecular Friedel-Crafts acylation. The third, and preferred route to this compound involves a sequential malonate alkylation and acylation and ring-closure sequence.
