228720-63-6

Upstream product

• 33692-63-6 dimethyl N-(para-methoxyphenyl)-dithio-carbonimidate 
• 13831-31-7 Acetoxyacetyl chloride 

Downstream Products

• 946069-56-3 1-(4'-methoxy-phenyl)-3-acetoxy-4,4-bis(methylsulfonyl)azetidin-2-one 
• 228720-70-5 1-(4'-methoxyphenyl)-3-hydroxy-4,4-bis(methylthio)azetidin-2-one 
• 228720-65-8 (+/-)-1-(4'-methoxyphenyl)-3-hydroxy-azetidin-2-one 
• 228720-64-7 1-(4'-methoxyphenyl)-3-acetoxy-azetidin-2-one 
• 87568-43-2 1-(4'-methoxyphenyl)-azetidin-2,3-dione 

Relevant academic research and scientific papers

4,4-Bis(methylthio)azetidin-2-ones as synthons of 1,2- and 1,3-dicarbonyl systems

The importance of β-lactams as synthetic building blocks has been widely recognized in organic synthesis due to possible ring cleavage at any of the four single bonds of the β-lactam ring. We now report reactions involving breaking of the N1-C4 bond in differently substituted at C3 4,4-bis(methylthio)azetidin-2-ones, leading to formation of 1,2- and 1,3-dicarbonyl systems.

Chemo-enzymatic synthesis of chiral 3-hydroxy-azetidin-2-ones

n-Tributyltin hydride reduction of 3-acetoxy-4,4-bis(alkylthio)- azetidin-2-ones 4a and 4b produces 4-unsubstituted azetidinone 5 and 4- alkylthio-azetidin-2-one 9 respectively. Azetidin-2,3-diones 8,11,13 which can be conveniently prepared by basic hydro