87568-43-2Relevant articles and documents
Chemo-enzymatic synthesis of chiral 3-hydroxy-azetidin-2-ones
Bari,Madan,Sethi
, p. 10 - 17 (2007/10/03)
n-Tributyltin hydride reduction of 3-acetoxy-4,4-bis(alkylthio)- azetidin-2-ones 4a and 4b produces 4-unsubstituted azetidinone 5 and 4- alkylthio-azetidin-2-one 9 respectively. Azetidin-2,3-diones 8,11,13 which can be conveniently prepared by basic hydro
Synthesis of β-lactam antibiotics by the sulfeno-cycloamination
Ihara,Haga,Yonekura,et al.
, p. 7345 - 7352 (2007/10/02)
A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.