22875-63-4

Basic information

• Product Name: ethyl 2-(2-oxopiperidin-1-yl)acetate
• Synonyms: ethyl 2-(2-oxopiperidin-1-yl)acetate;(2-OXO-PIPERIDIN-1-YL)-ACETIC ACID ETHYL ESTER;Ethyl (2-oxopiperidin-1-yl)acetate;2-(2-keto-1-piperidyl)acetic acid ethyl ester;2-(2-oxo-1-piperidinyl)acetic acid ethyl ester;ethyl 2-(2-oxo-1-piperidyl)acetate;ethyl 2-(2-oxopiperidin-1-yl)ethanoate
• CAS NO: 22875-63-4
• Molecular Formula: C₉H₁₅NO₃
• Molecular Weight: 185.221
• Mol File: 22875-63-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(2-oxopiperidin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-oxopiperidin-1-yl)acetate(22875-63-4)
• EPA Substance Registry System: ethyl 2-(2-oxopiperidin-1-yl)acetate(22875-63-4)

Safety Data

• Hazardous Substances Data: 22875-63-4(Hazardous Substances Data)

Upstream product

• 675-20-7 piperidin-2-one 
• 105-36-2 ethyl bromoacetate 
• 5414-21-1 5-bromopentan-1-nitrile 
• 132353-41-4 2-(4'-Bromobutyl)-5-ethoxyoxazole 
• 22041-19-6 ethyl 2-(pyrrolidin-1-yl) acetate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 223254-30-6 1-{4-hydroxy-5-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-2-oxo-pentyl}-piperidin-2-one 
• 67088-92-0 ethyl-2-(2,4-dichlorophenylhydrazono)-1-piperidineacetate 
• 223253-54-1 1-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-5-(2-oxo-piperidin-1-yl)-pentane-2,4-dione 

Relevant articles and documents

Silica gel and microwave-promoted synthesis of dihydropyrrolizines and tetrahydroindolizines from enaminones

A wide range of N-(ethoxycarbonylmethyl)enaminones, prepared by the Eschenmoser sulfide contraction between N-(ethoxycarbonylmethyl) pyrrolidine-2-thione and various bromomethyl aryl and heteroaryl ketones, underwent cyclization in the presence of silica gel to give ethyl 6-(hetero)aryl-2,3-dihydro-1H-pyrrolizine-5-carboxylates within minutes upon microwave heating in xylene at 150 °C. Instead of functioning as a nucleophile, the enaminone acted as an electrophile at its carbonyl group during the cyclization. Yields of the bicyclic products were generally above 75%. The analogous microwave-assisted reaction to produce ethyl 2-aryl- 5,6,7,8-tetrahydroindolizine-3-carboxylates from (E)-ethyl 2-[2-(2-oxo-2-arylethylidene)piperidin-1-yl]acetates failed in nonpolar solvents, but occurred in ethanol at lower temperature and microwave power, although requiring much longer time. A possible mechanism for the cyclization is presented, and further functionalization of the newly created pyrrole ring in the dihydropyrrolizine core is described.

Novel heterocycles as selective α1-adrenergic receptor antagonists

A novel series of aryl piperazine substituted heterocycles has been synthesized and identified as antagonists of the α(1a)-adrenergic receptor (α(1a)-AR), which has been implicated in benign prostatic hyperplasia (BPH). These compounds selectively inhibit binding to the α(1a)-AR with K(i)s as low as 2.1 nM. (C) 2000 Elsevier Science Ltd.

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists having the structure, for example, of STR1 for example STR2