228874-05-3

Basic information

• Product Name: 1-benzyl-4-(3-methyl-5-phenyl-pyrazol-1-yl)-piperidine
• CAS NO: 228874-05-3
• Molecular Weight: 331.461
• Mol File: 228874-05-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(3-methyl-5-phenyl-pyrazol-1-yl)-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(3-methyl-5-phenyl-pyrazol-1-yl)-piperidine(228874-05-3)
• EPA Substance Registry System: 1-benzyl-4-(3-methyl-5-phenyl-pyrazol-1-yl)-piperidine(228874-05-3)

Safety Data

• Hazardous Substances Data: 228874-05-3(Hazardous Substances Data)

Upstream product

• 93-91-4 1-phenylbutan-1,3-dione 
• 180696-11-1 1-benzyl-4-hydrazinylpiperidine 

Relevant articles and documents

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains

Replacement of the flexible connecting chains between the piperidine moiety and an aromatic group in previous CCR5 antagonists with heterocycles, such as pyrazole and isoxazole, provided potent CCR5 antagonists with excellent anti-HIV-1 activity in vitro. SAR studies revealed optimal placement of an unsubstituted nitrogen atom in the heterocycle to be meta to the bond connected to the 4-position of piperidine. Truncation of a benzyl group to a phenyl group afforded compounds with dramatically improved oral bioavailability, albeit with reduced activity.