228997-10-2

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 109-89-7 diethylamine 
• 228997-09-9 3,5-bis(methoxymethoxy)benzoic acid 
• 76280-59-6 methyl 3,5-bis(methoxymethoxy)benzoate 

Downstream Products

• 228997-25-9 (5R,10aR)-6,8-bis(benzyloxy)-5-<<4-(benzyloyx)phenyl>methyl>-9-<<(4-methoxyphenyl)methyl>thio>-1,5,10,10a-tetrahydroxazolo<3,4-b>isoquinolin-3(3H)-one 
• 228997-23-7 (1R,3R)-6,8-bis(benzyloxy)-1-<(4-(benzyloxy)phenyl)methyl>-5-<<(4-methoxyphenyl)methyl>thio>-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester 
• 228997-24-8 (1R,3R)-6,8-bis(benzyloxy)-1-<<4-(benzyloxy)phenyl>methyl>-3-hydroxymethyl-5-<<(4-methoxyphenyl)methyl>thio>-1,2,3,4-tetrahydroisoquinoline 
• 228997-22-6 N-<<4-(benzyloxy)phenyl>acetyl>-3,5-bis(benzyloxy)-2-<<(4-methoxyphenyl)methyl>thio>-D-phenylalanine methyl ester 
• 228997-26-0 (5R,10aR)-6,8-bis(benzyloxy)-5-<<4-(benzyloyx)phenyl>methyl>-9-mercapto-1,5,10,10a-tetrahydroxazolo<3,4-b>isoquinolin-3(3H)-one 
• 228997-18-0 (2S-trans)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-bis(benzyloxy)-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine 
• 228997-19-1 (2S-cis)-2,5-dihydro-3,6-dimethoxy-5-<<3,5-bis(benzyloxy)-2-<<(4-methoxyphenyl)methyl>thio>phenyl>methyl>-2-(1-methylethyl)pyrazine 
• 228997-20-4 3,5-bis(benzyloxy)-2-<<(4-methoxyphenyl)methyl>thio>-D-phenylalanine methyl ester 
• 228997-13-5 3,5-bis(benzyloxy)-N,N-diethyl-2<<(4-methoxyphenyl)methyl>thio>benzamide 
• 228997-14-6 3,5-bis(benzyloxy)-N,N-diethyl-2<<(4-methoxyphenyl)methyl>thio>benzenemethanamine 
• 228997-29-3 3,5-bis(benzyloxy)-1-(chloromethyl)-2-<<(4-methoxxyphenyl)methyl>thio>benzene 
• 228997-12-4 N,N-diethyl-3,5-dihydroxy-2-<<(4-methoxyphenyl)methyl>thio>benzamide 
• 228997-11-3 N,N-diethyl-3,5-bis(methoxxymethoxy)-2-<<(4-methoxyphenyl)methyl>thio>benzamide 

Relevant academic research and scientific papers

Synthetic studies on the starfish alkaloid imbricatine. A chiral synthesis of tri-O-methylimbricatine

A detailed account is given of the chiral synthesis of tri-O- methylimbricatine (3), the triO-methyl derivative of the structurally unique benzyltetrahydroisoquinoline alkaloid imbricatine (2) isolated from the starfish Dermasterias imbricata. The route begins with the asymmetric synthesis of the sulfur-containing D-phenylalanine derivative (R)-11a and includes its conversion into the cis-benzyltetrahydroisoquinoline moiety 26a possessing the thiol group and construction of the 5-arylthio-3-methyl-L- histidine portion. The correctness of the structure and absolute configuration proposed for imbricatine has been unequivocally confirmed as a result of the present synthesis.