229008-39-3

Basic information

• Product Name: 4-((N-3-hydroxypropyl-N-methyl)aminomethyl)-aniline
• Synonyms: 4-((N-3-hydroxypropyl-N-methyl)aminomethyl)-aniline
• CAS NO: 229008-39-3
• Molecular Weight: 194.277
• Mol File: 229008-39-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-((N-3-hydroxypropyl-N-methyl)aminomethyl)-aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((N-3-hydroxypropyl-N-methyl)aminomethyl)-aniline(229008-39-3)
• EPA Substance Registry System: 4-((N-3-hydroxypropyl-N-methyl)aminomethyl)-aniline(229008-39-3)

Safety Data

• Hazardous Substances Data: 229008-39-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 555-16-8 4-nitrobenzaldehdye 
• 56553-60-7 sodium tris(acetoxy)borohydride 
• 156-87-6 propan-1-ol-3-amine 
• 1038231-31-0 3-((4-nitrobenzyl)amino)propan-1-ol 
• 229008-38-2 3-[methyl-(4-nitro-benzyl)-amino]-propan-1-ol 

Downstream Products

• 229005-67-8 N-(4-((N-3-hydroxypropyl-N-methyl)aminomethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229005-94-1 N-(4-((N-3-hydroxypropyl-N-methyl)aminomethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxamide 
• 229005-66-7 N-(4-((N-3-hydroxypropyl-N-methyl)aminomethyl)phenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 

Relevant articles and documents

Quaternary ammonium salts and their use

This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is -CH2-, -S- or -O-; and R2, R3 and R4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

The search for new small-molecule CCR5 antagonists by high-throughput screening (HTS) of the Takeda chemical library using [125I]RANTES and CHO/CCR5 cells led to the discovery of lead compounds (A, B) with a quaternary ammonium or phosphonium m