229008-41-7Relevant academic research and scientific papers
Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma
Lagu, Bharat,Gerchak, Chrissy,Pan, Meng,Hou, Cuifen,Singer, Monica,Malaviya, Ravi,Matheis, Michele,Olini, Gil,Cavender, Druie,Wachter, Michael
, p. 4382 - 4386 (2008/02/09)
A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characte
QUATERNARY SALT CCR2 ANTAGONISTS
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Page/Page column 65-67; 72-74, (2008/06/13)
Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
Quaternary salt CCR2 antagonists
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Page/Page column 75; 80, (2008/06/13)
Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
Quaternary ammonium salts and their use
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, (2008/06/13)
This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is -CH2-, -S- or -O-; and R2, R3 and R4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.
Anilide derivative, production and use thereof
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, (2008/06/13)
This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.
