229018-17-1 Usage
Description
2-HydroxyMelatonin is a metabolite of Melatonin, a hormone that is present in animals, plants, and microbes. It plays a significant role in regulating various biological processes, including sleep-wake cycles, immune function, and apoptosis. 2-HydroxyMelatonin has been found to have potential applications in the field of medicine, particularly in cancer treatment and drug delivery systems.
Uses
Used in Anticancer Applications:
2-HydroxyMelatonin is used as an anticancer agent for its ability to inhibit the proliferation and metastasis of breast cancer cells. It achieves this by inhibiting estrogen receptor action, which is a key factor in the development and progression of breast cancer. Additionally, 2-HydroxyMelatonin has been shown to enhance the apoptotic cell death of cancer cells while inhibiting apoptosis in immune cells and neurons, making it a promising candidate for cancer treatment.
Used in Drug Delivery Systems:
In order to improve the bioavailability and therapeutic outcomes of 2-HydroxyMelatonin, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for the delivery of 2-HydroxyMelatonin, aiming to enhance its effectiveness in cancer treatment. By utilizing these drug delivery systems, the limitations of 2-HydroxyMelatonin can be overcome, leading to improved treatment options for patients with cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 229018-17-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,9,0,1 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 229018-17:
(8*2)+(7*2)+(6*9)+(5*0)+(4*1)+(3*8)+(2*1)+(1*7)=121
121 % 10 = 1
So 229018-17-1 is a valid CAS Registry Number.
229018-17-1Relevant articles and documents
Simple synthesis of some 2-substituted melatonin derivatives
Lozinskaya, Natalia A.,Sosonyuk, Sergey E.,Volkova, Maria S.,Seliverstov, Michael Yu.,Proskurnina, Marina V.,Bachurin, Sergey E.,Zefirov, Nikolay S.
, p. 273 - 276 (2011/03/18)
A simple strategy for the synthesis of some 2-substituted melatonin derivatives using p-anisidine as starting material is reported. The key step is a chemoselective reduction of a cyano group in the presence of an appropriate acid anhydride by hydrogenation over Adams' catalyst or with sodium borohydride in the presence of catalytic amounts of anhydrous nickel(II) chloride. The 2-substituted melatonin derivatives were obtained in six or seven steps from inexpensive p-anisidine in 9-13% overall yield. Georg Thieme Verlag Stuttgart New York.
