229018-17-1

Usage

Uses

Used in Anticancer Applications:
2-HydroxyMelatonin is used as an anticancer agent for its ability to inhibit the proliferation and metastasis of breast cancer cells. It achieves this by inhibiting estrogen receptor action, which is a key factor in the development and progression of breast cancer. Additionally, 2-HydroxyMelatonin has been shown to enhance the apoptotic cell death of cancer cells while inhibiting apoptosis in immune cells and neurons, making it a promising candidate for cancer treatment.
Used in Drug Delivery Systems:
In order to improve the bioavailability and therapeutic outcomes of 2-HydroxyMelatonin, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for the delivery of 2-HydroxyMelatonin, aiming to enhance its effectiveness in cancer treatment. By utilizing these drug delivery systems, the limitations of 2-HydroxyMelatonin can be overcome, leading to improved treatment options for patients with cancer.

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Relevant academic research and scientific papers

Simple synthesis of some 2-substituted melatonin derivatives

A simple strategy for the synthesis of some 2-substituted melatonin derivatives using p-anisidine as starting material is reported. The key step is a chemoselective reduction of a cyano group in the presence of an appropriate acid anhydride by hydrogenation over Adams' catalyst or with sodium borohydride in the presence of catalytic amounts of anhydrous nickel(II) chloride. The 2-substituted melatonin derivatives were obtained in six or seven steps from inexpensive p-anisidine in 9-13% overall yield. Georg Thieme Verlag Stuttgart New York.

Uses of melatonin in skin

Melatonin, which can be produced in the skin, exerts a protective effect against damage induced by ultraviolet radiation (UVR). The present study investigated the effect of UVB, the most damaging component of UVR, on melatonin metabolism in HaCaT keratinocytes and in a cell-free system. Four metabolites were identified by HPLC and LC-MS: 6-hydroxymelatonin, AFMK, 2-hydroxymelatonin (the main intermediate between melatonin and AFMK) and 4-hydroxymelatonin. Concentrations of these photoproducts were directly proportional to UVR-dose and to melatonin substrate content, and their accumulation was time dependent. The UVR-dependent increase of AFMK and 2-hydroxymelatonin was also detected in keratinocytes, where it was accompanied by simultaneous consumption of intracellular melatonin. Of note, melatonin and its two major metabolites, 2-hydroxymelatonin and AFMK, were also detected in untreated keratinocytes, neither irradiated nor preincubated with melatonin. Thus, intracellular melatonin metabolism is enhanced under exposure to UVR. The additional biological activity of these individual melatonin metabolites increases the spectrum of potential actions of the recently identified cutaneous melatoninergic system.