2-HydroxyMelatonin

Base Information

Chemical Name:2-HydroxyMelatonin
CAS No.:229018-17-1
Molecular Formula:C13H16N2O3
Molecular Weight:248.27800
Hs Code.:
Mol file:229018-17-1.mol

Synonyms:N-[2-(2-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide;

Suppliers and Price of 2-HydroxyMelatonin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
2-Hydroxymelatonin
250mg
$ 460.00

TRC
2-Hydroxymelatonin
100mg
$ 1455.00

Medical Isotopes, Inc.
2-Hydroxymelatonin
100 mg
$ 2200.00

Crysdot
N-(2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide 95%
10mg
$ 253.00

Chemenu
N-(2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide 95%
10mg
$ 238.00

Alichem
N-(2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide
10mg
$ 400.00

Total 3 raw suppliers

Chemical Property of 2-HydroxyMelatonin

Chemical Property:

Melting Point:>124oC (dec.)
PSA：74.35000
LogP:1.95160
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

2-Hydroxymelatonin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-Hydroxymelatonin, is a metabolite of Melatonin (M215000), which is a hormone found in animals, plants, and microbes. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

Technology Process of 2-HydroxyMelatonin

There total 7 articles about 2-HydroxyMelatonin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 70351-49-4
(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile

: 108-24-7
acetic anhydride

: 229018-17-1
2-hydroxymelatonin

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; at 20 ℃; for 4h; under 760.051 Torr;
DOI:10.1055/s-0030-1258361

Reference yield:

: 73-31-4
5-methoxy-N-acetyl-tryptamine

: 229018-17-1
2-hydroxymelatonin

: 52450-38-1
N¹-acetyl-N²-formyl-5-methoxykynurenine

: 2208-41-5
6-hydroxymelatonin

: 39998-64-6
4-hydroxymelatonin

Guidance literature:: Product distribution / selectivity; UV-irradiation; Aqueous phosphate buffer;

Reference yield:

: 39755-95-8
5-methoxyisatine

: 229018-17-1
2-hydroxymelatonin

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,4-dioxane / 4 h / 25 °C

2: hydrogenchloride; zinc / water; ethyl acetate / 20 °C

3: 2-ethoxy-ethanol / 2.5 h / Reflux

4: platinum(IV) oxide; hydrogen; acetic acid / 4 h / 20 °C / 760.05 Torr

With hydrogenchloride; platinum(IV) oxide; hydrogen; acetic acid; triethylamine; zinc; In 1,4-dioxane; 2-ethoxy-ethanol; water; ethyl acetate; 1: Knoevenagel condensation;
DOI:10.1055/s-0030-1258361