229021-64-1 Usage
Uses
Used in Pharmaceutical Industry:
ACPA is used as a synthetic agonist for the cannabinoid receptor 1 (CB1R) for its potential therapeutic applications in various medical conditions. Its high selectivity for CB1R makes it a promising candidate for the development of targeted treatments.
Used in Research and Development:
ACPA is used as a research tool to study the effects and mechanisms of action of CB1 receptor agonists. This helps in understanding the role of CB1R in various physiological and pathological processes, which can lead to the development of new therapeutic strategies.
Used in Drug Delivery Systems:
ACPA can be employed in the development of novel drug delivery systems to enhance its bioavailability and therapeutic outcomes. By incorporating ACPA into various carriers, such as organic and metallic nanoparticles, its delivery and efficacy can be improved, potentially leading to better treatment options for patients.
Used in Combination Therapy:
ACPA may be used in combination with other therapeutic agents to enhance their efficacy and overcome resistance in various medical conditions. Its synergistic effects when combined with conventional treatments can provide additional benefits and improve patient outcomes.
Biological Activity
Potent and selective CB 1 agonist (K i = 2.2 nM). Displays 325-fold selectivity over CB 2 receptors. Active in vivo . Also available in water soluble emulsion (N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
Enzyme inhibitor
This highly selective, synthetic CB1 receptor agonist (FW = 343.55 g/mol; CAS 229021-64-1), also known as arachidonylcyclopropylamide and N(cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, targets CB1 cannabinoid receptor agonist (Ki = 2.2 nM) with >325-fold selectivity over CB2 receptors. Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. ACPA possesses the characteristics of CB1 receptor agonists, inhibiting forskolininduced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [35S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. See also ACEA
Check Digit Verification of cas no
The CAS Registry Mumber 229021-64-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,9,0,2 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 229021-64:
(8*2)+(7*2)+(6*9)+(5*0)+(4*2)+(3*1)+(2*6)+(1*4)=111
111 % 10 = 1
So 229021-64-1 is a valid CAS Registry Number.
