22903-23-7

Upstream product

• 128-39-2 2,6-di-tert-butylphenol 
• 950-58-3 2,6-di-tert-butyl-4-aminophenol 
• 108-24-7 acetic anhydride 
• 101213-98-3 N,N'-thiobis(2,6-di-t-butyl-1,4-benzoquinone imine) 

Relevant academic research and scientific papers

DPPH radical scavenging activity of paracetamol analogues

Biochemical studies suggest a direct relationship between the radical scavenging activity of paracetamol (I) and its antipyretic and analgesic action. To evaluate the effect of chemical modifications on the radical scavenging activity of compounds of type I, analogues 1-14 were prepared and submitted to a stable free radical (DPPH; 1,1-diphenyl-2-picryl-hydrazyl) assay. All paracetamol derivatives showed a significant higher efficiency than the parent compound. This study showed that radical scavenging activity can be increased by decreasing the phenolic ortho substituents steric hindrance or by introducing substituents on the acyl moiety like an indazole ring or the ionic N-methyl morpholinium group. A significant activating effect was also observed by replacing the 1,4-acylamidophenol with a 1,4-acylamidonaphthol system.

Method for making aminophenols and their amide derivatives

N-acylated dialkylaminophenols are produced at greater yields under mild reaction conditions by a novel in situ process which begins with catalytic hydrogenation of dialkylnitrosophenols in an aprotic organic reaction medium.

Sulphur Nitrides in Organic Chemistry. Part 16. The Reaction of Tetrasulphur Tetranitride with Alkyl- and Alkylhalophenols. Preparation of 2,1,3-Benzothiadiazoles.

The reaction of tetrasulphur tetranitride (N4S4) with alkylphenols 1a-o and alkylhalophenols 2a-i gave the corresponding 2,1,3-benzothiadiazoles 3a-n in 12-84percent yields.The reaction with 2,6-di-t-butylphenols 1p, q and 2j afforded N,N'-thiobis(1,4-ben