229174-01-0Relevant articles and documents
(2S,3S)- and (2R,3S)-2-[2-(benzyloxy)ethyl]-3-(6-chloro-9H-purin-9-yl)oxolane
Balayiannis, George,Argiris, Ioannis,Papaioannou, Dionissios,Kavounis, Constantin
, p. 1005 - 1008 (1999)
The title diastereomeric compounds, C18H19ClN4O2, are the products formed when the (2S,3S)- and (2R,3S)-3-(5-amino-6-chloropyrimidinyl)amino-2-(2-benzyloxy)ethyl-oxolanes are treated with triethyl orthoformate in the presence of 4-toluenesulfonic acid. The crystal structure determination unambiguously shows the cis and trans orientations, respectively, of the 2-benzyloxyethyl and the 6-chloropurinyl substituents of the oxolanyl ring.
Total syntheses of novel dideoxynucleoside analogues using chiral amino acids
Balayiannis,Karigiannis,Gatos,Papaioannou,De Clercq
, p. 6191 - 6194 (2007/10/03)
N-Tritylated L- and D-methionine and L-glutamic acid were used to obtain novel chiral iso-dideoxynucleoside analogues incorporating a tetrahydrofuranyl or a tetrahyropyranyl ring as the pseudosugar part, and at positions 2 and 3 of the ring an hydroxyethyl group and thymine or adenine, respectively. (C) 2000 Elsevier Science Ltd.