22918-01-0

Basic information

• Product Name: 2-Bromo-4-chloropyridine
• Synonyms: 2-BROMO-4-CHLOROPYRIDINE;4-CHLORO-2-BROMOPYRIDINE;Pyridine, 2-bromo-4-chloro-;2-broMo-4-pyridyl chloride;2-broMo -4-chlorine pyridine;2-Bromo-4-chloropyridine 95%
• CAS NO: 22918-01-0
• Molecular Formula: C₅H₃BrClN
• Molecular Weight: 192.44
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridine;Variety of halogenated heterocyclic series;Heterocycle-Pyridine series;alkyl bromide| alkyl chloride
• Mol File: 22918-01-0.mol

Chemical Properties

• Melting Point: <30℃
• Boiling Point: 98°C
• Flash Point: >110℃
• Appearance: light yellow liquid
• Density: 1.736 g/cm³
• Vapor Pressure: 0.19mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 0.12±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-chloropyridine(22918-01-0)
• EPA Substance Registry System: 2-Bromo-4-chloropyridine(22918-01-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• WGK Germany: 1
• Hazardous Substances Data: 22918-01-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

InChI:InChI=1/C5H3BrClN/c6-5-3-4(7)1-2-8-5/h1-3H

Upstream product

• 626-61-9 4-Chloropyridine 
• 19798-80-2 2-Amino-4-chloropyridine 
• 5470-22-4 4-chloropicolinic acid 

Downstream Products

• 139585-50-5 4-chloro-2-trimethylsilylpyridine 
• 139585-52-7 4-(Phenylsulfonyl)-2-(trimethylsilyl)pyridin 
• 1762-41-0 4,4'-dichloro-2,2'-bipyridine 
• 1035268-55-3 4-chloro-2-[(4-methoxyphenyl)ethynyl]pyridine 
• 1070870-41-5 2-bromo-4-chloro-3-iodopyridine 
• 1268619-59-5 3-(2-bromo-pyridin-4-yloxy)-benzoic acid 
• 1268619-60-8 3-(2-bromo-pyridin-4-yloxy)-N-m-tolyl-benzamide 
• 1268619-61-9 3-(2-bromo-pyridin-4-yloxy)-N-(2-fluoro-5-methyl-phenyl)-benzamide 
• 1268619-78-8 5-{4-[3-(2-fluoro-5-methyl-phenylcarbamoyl)-phenoxy]-pyridin-2-yl}-1H-pyrrole-3-carboxylic acid 
• 1268619-90-4 5-{4-[3-(2-fluoro-5-methyl-phenylcarbamoyl)-phenoxy]-pyridin-2-yl}-1H-pyrrole-3-carboxylic acid methyl ester 
• 1268619-77-7 N-(2-fluoro-5-methylphenyl)-3-[(2-{4-[(3-hydroxypyrrolidin-1-yl)carbonyl]-1H-pyrrol-2-yl}pyridin-4-yl)oxy]benzamide 
• 1345971-95-0 C₂HF₃O₂*C₂₆H₂₅ClF₃N₃O₂ 
• 1070870-42-6 2-bromo-4-chloro-3-(3-ethylphenyl)pyridine 
• 1433851-36-5 3-(acetoxymethyl)-2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)pyridin-4-ylboronic acid 

Relevant articles and documents

Purification method 2 -bromine -4 -chloropyridine

The purification method of 2 -bromo -4 -chloropyridine comprises the following steps: 1) 2 -bromo -4 -chloropyridine crude is added first organic solvent, excess sulfuric acid is added, and filtered to obtain first filtrates after being fully reacted. 2) The first filtrate was washed in second organic solvent, filtered to give second a filtrate. 3) The second filtrate was added third organic solvent, an excess of an aqueous alkaline aqueous solution was added, and the mixture was sufficiently reacted to obtain 2 - bromo -4 -chloro pyridine solution. The method is simple and feasible, and is suitable for industrial production.

Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.

RENIN INHIBITORS

Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.

RENIN INHIBITORS

Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.

First regioselective c-2 lithiation of 3- and 4-chloropyridines

We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lithiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.