22918-03-2 Usage
Uses
Used in Pharmaceutical Industry:
4-Chloro-2-iodopyridine is used as a synthetic intermediate for the preparation of disubstituted chloropyridine derivatives. It plays a crucial role in the development of new pharmaceutical compounds, particularly those with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Chloro-2-iodopyridine is used as a key building block for the creation of various complex molecules. Its unique structure allows for regioselective lithiation with butyllithium and dimethylaminoethanol, followed by substitution with electrophiles, enabling the synthesis of a wide range of chemical products.
Used in Research and Development:
4-Chloro-2-iodopyridine is also utilized in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 22918-03-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,9,1 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22918-03:
(7*2)+(6*2)+(5*9)+(4*1)+(3*8)+(2*0)+(1*3)=102
102 % 10 = 2
So 22918-03-2 is a valid CAS Registry Number.
22918-03-2Relevant articles and documents
First regioselective c-2 lithiation of 3- and 4-chloropyridines
Choppin, Sabine,Gros, Philippe,Fort, Yves
, p. 603 - 606 (2007/10/03)
We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lithiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.
