229323-96-0Relevant articles and documents
Efficient synthesis of gem-dihydroperoxides with molecular oxygen and anthraquinone under visible light irradiation with fluorescent lamp
Cui, Lei,Tada, Norihiro,Okubo, Hiroaki,Miura, Tsuyoshi,Itoh, Akichika
, p. 2347 - 2350 (2011)
We developed an efficient dihydroperoxidation protocol of various carbonyl compounds with molecular oxygen and anthraquinone in 2-propanol under visible light irradiation with a fluorescent lamp, which produced corresponding gem-dihydroperoxides in high yields.
Convenient synthesis of geminal bishydroperoxides by the reaction of ketones with hydrogen peroxide
Terent'ev,Platonov,Ogibin,Nikishin
, p. 1281 - 1287 (2007)
A convenient procedure was developed for the synthesis of geminal bishydroperoxides by the sulfuric acid-catalyzed reaction of ketones with hydrogen peroxide in THF. Gem-bishydroperoxides were prepared by the reactions of five- to seven-membered cycloalkanones without additional purification in 80-95% yields with a purity of more than 95%; their acyclic analogs were prepared in 43-72% yields. Copyright Taylor & Francis Group, LLC.
Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes
Tsuchiya, Kaoru,Hamada, Yoshiaki,Masuyama, Araki,Nojima, Masatomo,McCullough, Kevin J.,Kim, Hye-Sook,Shibata, Yasuharu,Wataya, Yusuke
, p. 4077 - 4080 (1999)
(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H2O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.
Perhydrolysis in Ethereal H2O2 Mediated by MoO2(acac)2: Distinct Chemoselectivity between Ketones, Ketals, and Epoxides
An, Xiaosheng,Zha, Qinghong,Wu, Yikang
supporting information, p. 1542 - 1546 (2019/02/26)
Ketones, ketals, and epoxides were converted into corresponding hydroperoxides in high yields by reaction with ethereal H2O2 in the presence of a catalytic amount of MoO2(acac)2 with distinct (to date unattainable) chemoselectivity.
Activation of aqueous hydrogen peroxide for non-catalyzed dihydroperoxidation of ketones by azeotropic removal of water
Starkl Renar,Pe?ar,Iskra
supporting information, p. 9369 - 9372 (2015/09/15)
Cyclic and acyclic ketones were selectively converted to gem-dihydroperoxides in 72-99% yield with 30% aq. hydrogen peroxide by azeotropic distillation of water from the reaction mixture without any catalyst. The reactions were more selective than with 100% H2O2 and due to neutral conditions also less stable products could be obtained.
Poly(N-vinylpyrrolidone)-H2O2 and poly(4-vinylpyridine)-H2O2 complexes: Solid H 2O2 equivalents for selective oxidation of sulfides to sulfoxides and ketones to gem-dihydroperoxides
Surya Prakash,Shakhmin, Anton,Glinton, Kevin E.,Rao, Sneha,Mathew, Thomas,Olah, George A.
supporting information, p. 3616 - 3622 (2014/07/08)
Complexes of poly(N-vinylpyrrolidone) (PVD) and poly(4-vinylpyridine) (PVP) with hydrogen peroxide have been prepared and their synthetic utility as solid H2O2 equivalents for the selective oxidation of sulfides to sulfoxides and ketones to gem-dihydroperoxides has been studied. These complexes are convenient and safe alternatives to H2O2 solutions and it is found that various symmetric as well as unsymmetrical sulfides undergo oxidation under mild conditions to provide the respective sulfoxides in high yields. A series of gem-dihydroperoxides were obtained from the corresponding ketones in good yields under ambient conditions. This journal is the Partner Organisations 2014.
Oxidative cleavage of C=C bonds with singlet molecular oxygen generated from monoacetylated bishydroperoxides
Azarifar, Davood,Najminejad, Zohreh
, p. 1377 - 1382 (2013/07/26)
The oxidative cleavage of C=C bonds adjacent to aryl and alkyl moieties was efficiently achieved with monoacetylated bishydroperoxides. The main active oxidant used in this reaction was singlet molecular oxygen, which was generated in situ from the base-mediated fragmentation of monoacetylated bishydroper oxides. All the reactions proceeded smoothly at room temperature to furnish the respective carbonyl compounds in good yields within short reaction times. Georg Thieme Verlag Stuttgart · New York.
Synthesis of alkyl hydroperoxides via alkylation of gem -dihydroperoxides
Kyasa, Shivakumar,Puffer, Benjamin W.,Dussault, Patrick H.
, p. 3452 - 3456 (2013/06/26)
2-Fold alkylation of 1,1-dihydroperoxides, followed by hydrolysis of the resulting bisperoxyacetals, provides a convenient method for synthesis of primary and secondary alkyl hydroperoxides.
Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives
Franco, Lucas Lopardi,de Almeida, Mauro Vieira,e Silva, Luiz Francisco Rocha,Vieira, Pedro Paulo Ribeiro,Pohlit, Adrian Martin,Valle, Marcelo Siqueira
experimental part, p. 790 - 797 (2012/06/18)
Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0μm≤IC50≤5.0μm) against blood forms of the human malaria parasite Plasmodium falciparum.
Triflic acid-functionalized silica-coated magnetic nanoparticles as a magnetically separable catalyst for synthesis of gem-dihydroperoxides
Liu, Yong-Hui,Deng, Jia,Gao, Jian-Wu,Zhang, Zhan-Hui
experimental part, p. 441 - 447 (2012/04/04)
Triflic acid-functionalized silica-coated magnetic nanoparticles [γ-Fe2O3@SiO2-TfOH] were readily prepared and identified as an effictive catalyst for the transformation of aldehydes or ketones into their corresponding gem-dihydroperoxides with 30% aqueous hydrogen peroxide. The catalyst was easily separated by magnetic decantation and the recovered catalyst was reused for seven cycles without significant loss of catalytic activity. Copyright
