229470-21-7

Upstream product

• 151864-81-2 ethyl 4-(3-oxopropyl)benzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 259145-25-0 4-(3-hydroxy-4-nitrobutyl)benzoic acid ethyl ester 

Downstream Products

• 229470-22-8 4-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-4-nitrobutyl]benzoic acid ethyl ester 
• 146943-43-3 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 
• 137281-39-1 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid 

Relevant academic research and scientific papers

A simple and concise synthesis of LY231514 (MTA)

The pyrrolo[2,3-d]pyrimidine anticancer agent LY231514 (MTA, 1) has been prepared utilizing, as a key sequence, Michael condensation of 2,6-diamino- 4(3H)-pyrimidinone (as the donor) with the nitro olefin 8, followed by a Nef reaction that leads to the annulated pyrrole ring of 1.