Tetrahedron Letters p. 4023 - 4026 (1999)
Update date:2022-07-29
Topics:
Taylor, Edward C.
Liu, Bin
The pyrrolo[2,3-d]pyrimidine anticancer agent LY231514 (MTA, 1) has been prepared utilizing, as a key sequence, Michael condensation of 2,6-diamino- 4(3H)-pyrimidinone (as the donor) with the nitro olefin 8, followed by a Nef reaction that leads to the annulated pyrrole ring of 1.
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Doi:10.1021/acs.jmedchem.1c00023
(2021)Doi:10.1021/ja01110a044
(1953)Doi:10.1002/aoc.6256
(2021)Doi:10.1021/bi00799a029
(1971)Doi:10.1021/ja990138l
(1999)Doi:10.1016/S0014-827X(99)00008-7
(1999)
