229485-47-6

Basic information

• Product Name: Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 5-hydroxy-3-methyl-2-phenyl-, ethyl ester
• CAS NO: 229485-47-6
• Molecular Formula: C16H15N3O3
• Molecular Weight: 297.313
• Mol File: 229485-47-6.mol

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 5-hydroxy-3-methyl-2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 5-hydroxy-3-methyl-2-phenyl-, ethyl ester(229485-47-6)
• EPA Substance Registry System: Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 5-hydroxy-3-methyl-2-phenyl-, ethyl ester(229485-47-6)

Safety Data

• Hazardous Substances Data: 229485-47-6(Hazardous Substances Data)

Upstream product

• 15400-53-0 ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate 
• 229484-39-3 ethyl 5,8-dihydro-3-methyl-5-oxo-8-(1-oxo-1-phenylpropan-2-yl)-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylate 

Downstream Products

• 229484-43-9 8-(2,6-difluorobenzyl)-5,8-dihydro-3-methyl-5-oxo-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 229484-52-0 8-(2,6-difluorobenzyl)-5,8-dihydro-3-methyl-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 229484-53-1 3-bromomethyl-8-(2,6-difluorobenzyl)-5,8-dihydro-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 229484-76-8 2-(4-aminophenyl)-8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 229484-63-3 8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 489473-32-7 C₃₃H₃₂F₂N₆O₅ 
• 229484-80-4 8-(2,6-difluorobenzyl)-5,8-dihydro-2-[4-(ethylaminocarbonylamino)phenyl]-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones.

The design and synthesis of a new class of nonpeptide luteinizing hormone-releasing hormone (LHRH) receptor antagonists, the 2-phenylimidazo[1,2-a]pyrimidin-5-ones, is reported. Among compounds described in this study, we identified the potent antagonist 15b with nanomolar in vitro functional antagonism. The result might suggest that the heterocyclic 5-6-ring system possessing a pendant phenyl group attached to the five-membered ring is the important structural feature for a scaffold of small molecule LHRH antagonists.

Nitrogen-containing heterocyclic compounds, their production and use

A compound of the formula: wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R1, R2 and R3 each is (i) H or (ii) a group bound via C, N, O or S; R4 is a group bound via C; R5 is H or a group bound via C or O; R6 is H or a group bound via C; R7 is a homo- or hetero-cyclic group which may be substituted; or a salt thereof possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful as a prophylactic or therapeutic agent for sex hormone-dependent diseases, and so forth.