849355-52-8Relevant academic research and scientific papers
New antiproliferative benzoindolinothiazepines derivatives
Laconde, Guillaume,Depreux, Patrick,Berthelot, Pascal,Pommery, Nicole,Henichart, Jean-Pierre
, p. 167 - 172 (2007/10/03)
New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.
Synthesis of substituted benzoindolinothiazepines using 5- And 6-nitroindolines
Laconde,Depreux,Berthelot,Henichart
, p. 39 - 43 (2007/10/03)
The synthesis of benzoindolothiazepine compounds was investigated using Friedel-Crafts reactions conditions from indolines. The amine function of indolinic identity was protected to avoid an alkylation of this function by methyl iodide. It was observed that the treatment of the desired amines with commercially available methyl chlorosulfanoylbenzonate resulted in the formation of sulfonamide compounds. It was also observed that the cyclization of the carboxylic acid under Friedel-Crafts conditions resulted in the formation of the desired tetracycles.
