22952-79-0 Usage
Class
Morphinan alkaloid derivative
Parent Compound
Morphinan, a natural opioid alkaloid from opium poppy plants
Functional Group
Sulfonate ester
Solubility
Increased water solubility due to the sulfonate ester group
Bioavailability
Potentially enhanced due to increased water solubility
Pharmacological Effects
Likely opioid-like effects due to structural similarity with morphine
Applications
Research in opioid receptors
Pharmaceutical applications in pain management
Substituents
3-methoxy group
4-methyl group
Impact of Substituents
May affect pharmacological properties and therapeutic uses
Check Digit Verification of cas no
The CAS Registry Mumber 22952-79-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,9,5 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22952-79:
(7*2)+(6*2)+(5*9)+(4*5)+(3*2)+(2*7)+(1*9)=120
120 % 10 = 0
So 22952-79-0 is a valid CAS Registry Number.
22952-79-0Relevant academic research and scientific papers
Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs
Cunningham, Christopher W.,Mercer, Susan L.,Hassan, Hazem E.,Traynor, John R.,Eddington, Natalie D.,Coop, Andrew
, p. 2316 - 2320 (2008/12/22)
Continuing our studies investigating opioids with reduced P-glycoprotein (P-gp) substrate activity, a series of known 3- and 6-hydroxy, -methoxy, and -desoxymorphine analogs was synthesized and analyzed for P-gp substrate activity and opioid binding affinity. 6-Desoxymorphine (7) showed high affinity for opioid receptors and did not induce P-gp-mediated ATP hydrolysis. Additionally, 7 demonstrated morphine-like antinociceptive potency in mice, indicating this compound as an ideal lead to further evaluate the role of P-gp in opioid analgesic tolerance development.
