22957-86-4

Upstream product

• 108-24-7 acetic anhydride 
• 65934-74-9 3-(trifluoromethyl)-4-methylaniline 
• 56-23-5 tetrachloromethane 
• 103-89-9 4-Methylacetanilide 

Downstream Products

• 579474-27-4 N-(4-methyl-2-nitro-5-trifluoromethyl-phenyl)-acetamide 
• 28944-23-2 N-(4-methyl-2-nitro-3-trifluoromethyl-phenyl)-acetamide 
• 28956-76-5 (2S,3R,4S,5R)-6-(4-Methyl-2-nitro-5-trifluoromethyl-phenylamino)-hexane-1,2,3,4,5-pentaol 
• 28944-29-8 2-(4-Methyl-2-nitro-5-trifluoromethyl-phenylamino)-ethanol 
• 28944-28-7 3-Chlor-6-methyl-2-nitrobenzotrifluorid 
• 1644-12-8 5-Chlor-2-methyl-4-nitro-benzotrifluorid 
• 28944-25-4 3-Amino-6-methyl-2-nitrobenzotrifluorid 
• 22957-87-5 4-Methyl-2-nitro-5-trifluoromethyl-phenylamine 

Relevant academic research and scientific papers

Regioselective electrophilic trifluoromethylation of substituted anilines and derivatives in superacid

In a one pot procedure, treatment of chloro or methyl substituted acetanilides in HF/SbF5/CCl4 followed by addition of HF/pyridine yields trifluoromethyl derivatives with high regioselectivity.

COMBINATION OF MGLUR2 ANTAGONIST AND ACHE INHIBITOR FOR TREATMENT OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS

The present invention relates to a method of treatment or prevention of acute and/or chronic neurological disorders, to a pharmaceutical composition comprising an inhibitor of acetylcholinesterase (AChE inhibitor) and a metabotropic Glutamate receptor 2 antagonist (mGluR2 antagonist), to the use of an AChE inhibitor and a mGluR2 antagonist in the preparation of a medicament, and. to kits comprising an AChE inhibitor and a mGluR2 antagonist.

Dihydro-benzo[b][1,4]diazepin-2-one derivatives

This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.