22958-99-2

Basic information

• Product Name: [4-(CHLOROSULFONYL)PHENYL]ACETICACID
• Synonyms: 4-(Carboxymethyl)benzenesulphonyl chloride;4-(Chlorosulphonyl)phenylacetic acid, tech;4-(CarboxyMethyl)benzenesulfonyl Chloride;4-(Chlorosulfonyl)benzeneacetic Acid;2-(4-(chlorosulfonyl)phenyl)acetic acid
• CAS NO: 22958-99-2
• Molecular Formula: C₈H₇ClO₄S
• Molecular Weight: 234.66
• Product Categories: Phenyls & Phenyl-Het;Sulphonyl Chlorides;Phenyls & Phenyl-Het;Sulphonyl Chlorides;Sulfonyl Chlorides;Sulfur & Selenium Compounds
• Mol File: 22958-99-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 134-136°C
• Appearance: /
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: [4-(CHLOROSULFONYL)PHENYL]ACETICACID(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(CHLOROSULFONYL)PHENYL]ACETICACID(22958-99-2)
• EPA Substance Registry System: [4-(CHLOROSULFONYL)PHENYL]ACETICACID(22958-99-2)

Safety Data

• Hazardous Substances Data: 22958-99-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 103-82-2 phenylacetic acid 
• 7790-94-5 chlorosulfonic acid 
• 122-79-2 Phenyl acetate 

Downstream Products

• 39161-84-7 4-mercaptophenylacetic acid 
• 63271-86-3 2-(3-mercaptophenyl)acetic acid 
• 402-57-3 (4-fluorosulfonyl-phenyl)-acetic acid 
• 261524-34-9 2-[4-(methylaminosulfonyl)phenyl]acetic acid 
• 53305-12-7 2-(4-(chlorosulfonyl)phenyl)acetic acid methyl ester 
• 1599441-88-9 3-(4-chlorophenyl)-1-methyl-4-(4-sulfonamidophenyl)-1Hpyrrole-2,5-dione 
• 1599441-87-8 C₁₈H₁₆N₂O₅S 
• 1599441-86-7 C₁₈H₁₆N₂O₄S 
• 1599441-85-6 C₁₇H₁₄N₂O₄S 
• 1646490-60-9 MPO-0029 
• 1646490-59-6 C₁₇H₁₃NO₆S 
• 1646490-58-5 C₁₇H₁₃NO₅S 
• 1599441-84-5 C₁₆H₁₁ClN₂O₄S 
• 1415703-99-9 C₁₆H₁₁NO₅S 

Relevant articles and documents

Synthesis of a Potent Pan-Serotype Dengue Virus Inhibitor Having a Tetrahydrothienopyridine Core

A synthesis of the first-in-class pan-serotype dengue virus inhibitor NITD-688 is presented. The Gewald reaction of N-(tert-butoxycarbonyl)-6,6-dimethylpiperidin-3-one with malononitrile and sulfur in the presence of l-proline as a catalyst gave tert-buty

BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR

The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.