22960-25-4

Upstream product

• 126798-63-8 Phenyl-(1-phenyl-1H-isoquinolin-2-yl)-methanone 
• 126798-66-1 (4-Bromo-1-phenyl-1H-isoquinolin-2-yl)-phenyl-methanone 
• 3297-72-1 1-phenylisoquinoline 

Downstream Products

• 66728-99-2 4-amino-1-phenylisoquinoline 
• 90829-26-8 N-(2-(Diethylamino)-ethyl)-1-phenylisoquinoline-4-carboxylic acid amide 
• 41969-01-1 1-phenyl-4-isoquinolinecarbonitrile 
• 25365-84-8 3-methoxy-1-phenyl-1H-isoindole 
• 104704-43-0 4-azido-1-phenylisoquinoline 
• 104704-45-2 5-Methoxy-1-phenyl-1H-benzo[e][1,3]diazepine 
• 104704-49-6 C₂₀H₂₀N₂O₄ 
• 35393-41-0 3-Phenyl-3H-isoindol-1-ylamine; hydrochloride 

Relevant academic research and scientific papers

Heterocyclic Enamides Studies. I. Preparation of 4-Bromo- and 4-Chloroisoquinolines from 1,2-Dihydroisoquinoline Derivatives

The reactions of isoquinoline Reissert compounds analogs 1 with bromine and phosphorus pentachloride as well as the hydrolysis of enamides 1, 2 and 3 have been studied.Compounds 1 treated with bromine in most cases undergo bromination of unsaturated carbon C-4; when treated with PCl5 only 1-phenyl and 1-(2,4,6-trinitrobenzyl) derivatives undergo analogous chlorination.Acidic or basic hydrolysis of starting enamides and their 4-halogeno derivatives results in aromatization with splitting off or retention of substituents at C-1.The sequence of reactions studied can be used as a new interesting route to some 4-bromo or 4-chloroisoquinolines.

Isoquinoline derivatives, pharmaceutical formulations based on these compounds and the use thereof

Isoquinoline-4-carboxylic acid derivatives of the formula I STR1 in which m, n, R1, R2, R3, A and X have the meansings indicated, and physiologically acceptable acid addition salts thereof, a process for their preparation, pharmaceutical formulations based on these compounds and the use thereof as antiarrythmic agents.