22964-38-1

Upstream product

• 120-07-0 2,2'-(phenylimino)bis[ethanol] 
• 124-63-0 methanesulfonyl chloride 
• 62-53-3 aniline 

Downstream Products

• 1268488-03-4 C₁₉H₂₅N₅O₄S₃ 
• 1268488-04-5 C₁₉H₂₅N₅O₄S₃ 
• 99169-09-2 N,N-bis(2-azidoethyl)aniline 
• 1260401-24-8 (E)-2-(3-(4-(bis(2-azidoethyl)amino)styryl)-5,5-dimethylcyclohex-2-enylidene)malononitrile 
• 1260401-35-1 4-(bis(2-azidoethyl)amino)benzaldehyde 
• 553-27-5 aniline mustard 
• 1268821-28-8 4'-phenylspiro[indoline-1,1'-piperazin]-1-ium chloride 
• 240797-81-3 10-phenyl-1,4-dioxa-7,13-dithia-10-aza-cyclopentadecane 
• 2045-19-4 N,N-bis(2-bromoethyl)phenylamine 
• 29523-51-1 N,N-bis(2-iodoethyl)-N-phenylamine 

Relevant academic research and scientific papers

Universal dark quencher based on "clicked" spectrally distinct azo dyes

The first synthesis of an heterotrifunctional molecular scaffold derived from the popular DABCYL azo dye quencher has been achieved. The sequential derviatization of this trivalent azobenzene derivative with two other nonfluorescent azo dyes (Black Hole Q

Coupling selectivity with sensitivity in an integrated chemosensor framework: Design of a Hg2+-responsive probe, operating above 500 nm

For the highly selective and sensitive sensing of Hg2+ in water, a new design concept was realized where the selectivity of the probe's binding site is amplified by electronic properties of the chromophore. The molecular architecture of this ph

Solvent effect and amine interference on colorimetric changes of azobenzene-conjugated dithiaazadioxo crown ether mercury sensor

The colorimetric behavior of an azobenzene-based dye containing dithiaazadioxo ring for Hg2+-detection was investigated in diverse solvents. The mercury specific ligand shows hypsochromic changes in pure and aqueous MeCN upon Hg2+-bi

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.

Near-infrared solid-state emitters based on isophorone: Synthesis, crystal structure and spectroscopic properties

A series of near-infrared solid-state emitters based on the dicyanoisophorone electron acceptor group was synthesized. The solid-state spectroscopic properties were studied by UV-visible absorption spectroscopy and fluorescence spectroscopy and analyzed i

Hg2+ and Cu2+ selective detection using a dual channel receptor based on thiopyrylium scaffoldings

2,4,6-Triphenylthiopyrylium functionalized with an aza-oxa-thia macrocycle is able to selectively recognize Hg2+ cation by a color change and Cu2+ cation by a remarkable significant emission enhancement.

Mixed-Ligand Arenechromium Carbonyl Complexes as Electronic Modulators

A number of mixed ligand η6 arenechromium carbonyl complexes have been prepared and investigated for their ability to effect electronic modulation of arene chemistry. In the case of an aniline-derived system, the arenechromium carbonyl complex is able to modulate the inductive capacity of the aniline nitrogen atom and thus, regulate its anchimeric ability. In the case of 8-phenylmenthol and benzyloxazolidinone derivatives, modulation of arene π basicity is achieved, and results suggest that important vinylarene π-π interactions exist in acrylate derivatives of these chiral auxiliary systems.

Hypoxia-Selective Antitumor Agents. 3. Relationships between Structure and Cytotoxicity against Cultured Tumor Cells for Substituted N,N-Bis(2-chloroethyl)anilines

A series of aniline mustards with a wide range of electron-donating and -withdrawing substituents in the 3- and 4-positions has been synthesized and evaluated for cytotoxicity in cell culture to examine the potential of using nitro group deactivated nitrogen mustards for the design of novel hypoxia-selective anticancer drugs (Denny, W.A.; Wilson, W.R.J.Med Chem. 1986, 29, 879).Hydrolytic half-lives in tissue culture media, determined by bioassay against a cell line (UV4) defective in the repair of DNA interstrand cross-links showed the expected dependence on the Hammett electronic parameter, ?, varying from 0.13 h for the 4-amino analogue to >100 h for analogues with strongly electron-withdrawing substituents.Cytotoxic potencies in aerobic UV4 cultures showed a similar dependence on ?.This dependence predicted that the 4-nitroaniline mustard would be 7200-fold less potent than its potential six-electron reduction product, the 4-amino compound, in growth inhibition assays using a 1-h drug exposure.The measured differential was much lower (225-fold) because of the instability of the latter compound, but a differential of 17500-fold was observed in the initial rate of killing by using a clonogenic assay.The potential for formation of reactive mustards by reduction to the amine or hydroxylamine was demonstrated by the 4-nitroso compound, which had an aerobic toxicity similar to that of the amine.Although these features confirmed the original rationale, the 3-nitro- and 4-nitroaniline mustards had only minimal hypoxic selectivity against UV cells.Toxicity to hypoxic cells appears to be limited by the low reduction potentials of these compounds and consequent lack of enzymatic nitroreduction.However, this study has demonstrated that nitro groups can be used to latentiate aromatic nitrogen mustards and indicates that examples with higher reduction potentials could provide useful hypoxia-selective therapeutic agents.