229646-52-0

Upstream product

• 493026-63-4 3-(tert-butoxycarbonylamino)-N-[[1-(4-pyridinyl)-4-piperidinyl]methyl]alanine ethyl ester 
• 229647-17-0 6-oxo-1-[[1-(4-pyridinyl)-4-piperidinyl]methyl]-2-piperazinecarboxylic acid ethyl ester 
• 229647-08-9 1-(4-pyridinyl)-4-piperidinecarboxaldehyde 
• 130658-67-2 4-hydroxymethyl-1-(pyridin-4-yl)piperidine 
• 229646-51-9 4-[(6-chloro-2-naphthalenyl)sulfonyl]-6-oxo-1-[[1-(4-pyridinyl)-4-piperidinyl]methyl]-2-piperazinecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as a factor Xa inhibitor II. Substituent effect on biological activities

Intravascular clot formation is an important event in a number of cardiovascular diseases. The prevention of blood coagulation has become a major target for new therapeutic agents. Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in

AROMATIC COMPOUNDS HAVING CYCLIC AMINO OR SALTS THEREOF

Compounds represented by general formula (I) or salts thereof which specifically inhibit FXa, exert a potent anticoagulant effect and thus are useful as medicinal compositions, wherein G1 to G4, X and Y represent each CH or N; Z1 represents -SO2- or -CH2 -; Q represents aryl or heteroaryl; and R1 to R9 represent each hydrogen or a substituent.