2297-94-1

Basic information

• Product Name: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one
• Synonyms: 2,4,6-cycloheptatrien-1-one, 2-hydroxy-5-nitroso-; 2-Hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one
• CAS NO: 2297-94-1
• Molecular Formula: C₇H₅NO₃
• Molecular Weight: 151.1195
• Mol File: 2297-94-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 257.753°C at 760 mmHg
• Flash Point: 109.685°C
• Density: 1.335g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one(2297-94-1)
• EPA Substance Registry System: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one(2297-94-1)

Safety Data

• Hazardous Substances Data: 2297-94-1(Hazardous Substances Data)

Upstream product

• 2267-32-5 5,5,6,6-tetrafluoro-cyclohepta-1,3-diene 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 1502-10-9 1-methylimino-2-methylaminotropolone 

Downstream Products

• 132653-78-2 1-Hydroxy-6-p-tolyl-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 
• 132653-69-1 5-Hydroxy-8-p-tolyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132653-70-4 5-Hydroxy-8-p-tolyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132677-63-5 6-p-Tolyl-1-p-tolylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 132653-84-0 6-p-Tolyl-1-p-tolylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 132653-71-5 5-Hydroxy-8-phenyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132653-72-6 5-Hydroxy-8-phenyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132653-85-1 6-Phenyl-1-phenylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 132653-86-2 6-Phenyl-1-phenylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 47308-93-0 2-<2-(4-Nitrobenzoyl)-hydrazino>-5-nitroso-tropon 
• 742-62-1 2-<2-(4-Dimethylamino-benzoyl)-hydrazino>-5-nitroso-tropon 
• 744-52-5 2-<2-(4-Nitrobenzylcarbonyl)-hydrazino>-5-nitroso-tropon 
• 60423-21-4 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one 
• 1616515-31-1 C₁₉H₂₀O₅ 

Relevant articles and documents

SYNTHESES AND THERMAL PROPERTIES OF NEW LIQUID CRYSTALLINE MATERIALS INVOLVING TROPOLONE.

Two- and 3-ring compounds were prepared to examine the effect of a tropolone ring system on mesomorphic behavior. The 2-ring compounds are non-mesogenic whereas the 3-ring compounds exhibit nematic phases of high stability when R equals alkyl or alkoxy, X equals minus CH equals N minus or minus N equals N minus , and Y equals OH or OCH//3, and an additional smectic phase when R equals alkoxy. The nematic phase tends to align homeotropically when placed between two glass plates.

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS

Disclosed are a series of compounds or their tautomers having a general structure represented by Formula la or lb and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising said compounds or tautomers or pharmaceutically acceptable salts thereof. Further disclosure relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis, comprising administering to a subject in need thereof a therapeutically effective amount of Formula la or lb compounds or tautomers or pharmaceutically acceptable salts thereof.

Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase

Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn2+-dependent virulence factor, Pseudomonas aeruginosa elastase (LasB). Based on this initial hit, a series of substituted tropolone-based LasB inhibitors was prepared, and a compound displaying potent activity in vitro and in a bacterial swarming assay was identified. Importantly, this inhibitor was found to be specific for LasB over other metalloenzymes, validating the usage of tropolone as a viable scaffold for identifying first-in-class LasB inhibitors.