2297-94-1

Basic information

• Product Name: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one
• Synonyms: 2,4,6-cycloheptatrien-1-one, 2-hydroxy-5-nitroso-; 2-Hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one
• CAS NO: 2297-94-1
• Molecular Formula: C₇H₅NO₃
• Molecular Weight: 151.1195
• Mol File: 2297-94-1.mol

Chemical Properties

• Boiling Point: 257.753°C at 760 mmHg
• Flash Point: 109.685°C
• Density: 1.335g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one(2297-94-1)
• EPA Substance Registry System: 2-hydroxy-5-nitrosocyclohepta-2,4,6-trien-1-one(2297-94-1)

Safety Data

• Hazardous Substances Data: 2297-94-1(Hazardous Substances Data)

Upstream product

• 2267-32-5 5,5,6,6-tetrafluoro-cyclohepta-1,3-diene 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 1502-10-9 1-methylimino-2-methylaminotropolone 

Downstream Products

• 132653-78-2 1-Hydroxy-6-p-tolyl-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 
• 132653-69-1 5-Hydroxy-8-p-tolyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132653-70-4 5-Hydroxy-8-p-tolyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132677-63-5 6-p-Tolyl-1-p-tolylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 132653-84-0 6-p-Tolyl-1-p-tolylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 132653-71-5 5-Hydroxy-8-phenyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132653-72-6 5-Hydroxy-8-phenyl-8-aza-bicyclo[3.2.1]oct-3-ene-2,6-dione 2-oxime 
• 132653-85-1 6-Phenyl-1-phenylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 132653-86-2 6-Phenyl-1-phenylamino-6-aza-bicyclo[3.2.1]oct-2-ene-4,7-dione 4-oxime 
• 47308-93-0 2-<2-(4-Nitrobenzoyl)-hydrazino>-5-nitroso-tropon 
• 742-62-1 2-<2-(4-Dimethylamino-benzoyl)-hydrazino>-5-nitroso-tropon 
• 744-52-5 2-<2-(4-Nitrobenzylcarbonyl)-hydrazino>-5-nitroso-tropon 
• 54051-26-2 2-amino-5-nitroso-cycloheptatrienone 
• 3084-13-7 5-nitrotropolone 

Relevant articles and documents

SYNTHESES AND THERMAL PROPERTIES OF NEW LIQUID CRYSTALLINE MATERIALS INVOLVING TROPOLONE.

Two- and 3-ring compounds were prepared to examine the effect of a tropolone ring system on mesomorphic behavior. The 2-ring compounds are non-mesogenic whereas the 3-ring compounds exhibit nematic phases of high stability when R equals alkyl or alkoxy, X equals minus CH equals N minus or minus N equals N minus , and Y equals OH or OCH//3, and an additional smectic phase when R equals alkoxy. The nematic phase tends to align homeotropically when placed between two glass plates.

On the structure of 5-nitrosotropolone

It has long been discussed whether "5-nitrosotropolone" 1 takes the nitroso structure 1A or the tautomeric oxime structure 1B. Analysis of NMR and UV spectra data in this study indicates that the tropoquinone-5-monoxime 1B is preferred. The UV absorption shift to longer wavelength at dilute solutions is attributable to the dissociated form 3.

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS

Disclosed are a series of compounds or their tautomers having a general structure represented by Formula la or lb and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising said compounds or tautomers or pharmaceutically acceptable salts thereof. Further disclosure relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis, comprising administering to a subject in need thereof a therapeutically effective amount of Formula la or lb compounds or tautomers or pharmaceutically acceptable salts thereof.

Discovery of structurally simplified analogs of colchicine as an immunosuppressant

We have discovered a new class of colchicine-derived therapeutic agents for immune diseases including rejection of organ-transplantation and autoimmune disease. Compound 2, which had been developed to overcome poor pharmacokinetic properties of compound 1, a first-generation colchicine analog, turned out to show toxicity such as intestinal toxicity and loss of weight during in vivo tests. The deletion of 7-carboxamide group and middle ring-truncation in colchicine allowed us to have structurally simplified analogs with strong immunosuppressive activity. Herein, we report non-alkaloid tricyclic compound 7 and 12 as immunosuppressants which exhibited a strong immunosuppressive in vivo efficacy on the T-dependent antibody response, the Zymosan A-induced arthritis model and the Carrageenan-induced edema model. Compound 7 and 12 revealed less toxicity than the previous lead compound 2, and their minimum lethal doses (MLD) were proved to exceed 100 mg/kg.

Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase

Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn2+-dependent virulence factor, Pseudomonas aeruginosa elastase (LasB). Based on this initial hit, a series of substituted tropolone-based LasB inhibitors was prepared, and a compound displaying potent activity in vitro and in a bacterial swarming assay was identified. Importantly, this inhibitor was found to be specific for LasB over other metalloenzymes, validating the usage of tropolone as a viable scaffold for identifying first-in-class LasB inhibitors.

Methods for altering surface characteristics of microspheres

Various methods for altering surface characteristics of a microsphere are provided. One method includes coupling an enolic acid to the microsphere to modify the surface characteristics of the microsphere. The surface characteristics may include charge density and/or pKa. A reagent can be coupled to the microsphere via the enolic acid. The reagent may include a biomolecule. The modified surface characteristics may increase a stability of the reagent when the reagent is coupled to the microsphere. The modified surface characteristics may also improve performance of an assay carried out with the microsphere. Another embodiment relates to a microsphere that includes an enolic acid coupled to a polymer core of the microsphere such that the enolic acid modifies surface characteristics of the microsphere. A reagent can be coupled to the microsphere via the enolic acid.

TROPOLONE DERIVATIVE

Tropolone derivatives represented by the formula (I), which have retinoid actions and are useful as active ingredients of medicaments [R1 to R4 represent hydrogen atom, an alkyl group, or an alkoxyl group; the ring represented by Ar

Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure

Several tropolone derivatives (4-7) were designed as novel retinoids on the assumption that the tropolone ring may mimic the benzoic acid moiety in retinoid structures, such as Am80 (2). Among the synthesized compounds, 5-[2-(5,6,7,8-tetrahydro5,5,8,8-tetramethyl-2-naphthyl)ethynyl]tropolone (7a) showed moderate potency as a differentiation-inducer of HL-60 cells. The activities of the tropolones were greatly enhanced in the presence of HX630, an RXR agonist (retinoid synergist).