1616515-31-1

Basic information

• Product Name: C₁₉H₂₀O₅
• CAS NO: 1616515-31-1
• Molecular Weight: 328.365
• Mol File: 1616515-31-1.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₀O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₀O₅(1616515-31-1)
• EPA Substance Registry System: C₁₉H₂₀O₅(1616515-31-1)

Safety Data

• Hazardous Substances Data: 1616515-31-1(Hazardous Substances Data)

Upstream product

• 10385-36-1 2,3,4-trimethoxybromobenzene 
• 39240-15-8 1,2,3-trimethoxy-4-vinylbenzene 
• 343962-18-5 5-iodo-2-methoxytropone 
• 7021-46-7 5-aminotropolone 
• 2297-94-1 5-nitrosotropolone 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 22057-94-9 5-iodotropolone 

Relevant articles and documents

Discovery of structurally simplified analogs of colchicine as an immunosuppressant

We have discovered a new class of colchicine-derived therapeutic agents for immune diseases including rejection of organ-transplantation and autoimmune disease. Compound 2, which had been developed to overcome poor pharmacokinetic properties of compound 1, a first-generation colchicine analog, turned out to show toxicity such as intestinal toxicity and loss of weight during in vivo tests. The deletion of 7-carboxamide group and middle ring-truncation in colchicine allowed us to have structurally simplified analogs with strong immunosuppressive activity. Herein, we report non-alkaloid tricyclic compound 7 and 12 as immunosuppressants which exhibited a strong immunosuppressive in vivo efficacy on the T-dependent antibody response, the Zymosan A-induced arthritis model and the Carrageenan-induced edema model. Compound 7 and 12 revealed less toxicity than the previous lead compound 2, and their minimum lethal doses (MLD) were proved to exceed 100 mg/kg.