22978-83-2

Basic information

• Product Name: Pyrazine, tetramethyl-, 1-oxide (8CI,9CI)
• Synonyms: Pyrazine, tetramethyl-, 1-oxide (8CI,9CI);TETRAMETHYL-PYRAZINE,1-OXIDE
• CAS NO: 22978-83-2
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.19368
• Product Categories: PIPERIDINE
• Mol File: 22978-83-2.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazine, tetramethyl-, 1-oxide (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazine, tetramethyl-, 1-oxide (8CI,9CI)(22978-83-2)
• EPA Substance Registry System: Pyrazine, tetramethyl-, 1-oxide (8CI,9CI)(22978-83-2)

Safety Data

• Hazardous Substances Data: 22978-83-2(Hazardous Substances Data)

Upstream product

• 1124-11-4 Tetramethylpyrazine 
• 76494-51-4 2,3,5,6-tetramethylpyrazine hydrochloride 

Downstream Products

• 123624-90-8 2-(chloromethyl)-3,5,6-trimethylpyrazine 
• 186534-02-1 3,5,6-trimethyl-pyrazine-2-carbaldehyde 
• 1000672-71-8 (E)-2-(4-methoxylstyryl)-3,5,6-trimethylpyrazine 
• 1000672-72-9 (E)-2-(3,4-dimethoxylstyryl)-3,5,6-trimethylpyrazine 
• 1000672-73-0 2,3,5-trimethyl-6-((1E,3E)-4-phenylbuta-1,3-dienyl)pyrazine 

Relevant articles and documents

Oxidation methods for aromatic diazines: Substituted pyrazine-N-oxides, pyrazine-N,N′-dioxides, and 2,2′:6′,2″-terpyridine-1,1″-dioxide

In the course of investigations into the intermolecular interactions of azaaromatic N-oxides it was necessary to perform oxidations of the pyridine and pyrazine moieties. Generally, it was found that direct oxidation with OXONE gave efficient preparation of pyrazine dioxides. Oxidation with dimethyldioxirane was used to preclude problems associated with the isolation of particularly hydrophilic pyrazine and pyrazine-N-oxides.

Novel ligustrazine derivative as well as preparation method and application thereof

The invention provides a novel ligustrazine derivative as well as a preparation method and application thereof. Experiments prove that the ligustrazine derivative can effectively protect nerve cells and myocardial cells from CoCl2 hypoxia injury; and meanwhile, the ligustrazine derivative has the effect of remarkably inhibiting platelet aggregation. Therefore, the ligustrazine derivative disclosed by the invention can be used for preparing medicines for effectively preventing or treating central nervous system diseases and/or thrombotic diseases; more importantly, the effect of the ligustrazine derivative is obviously superior to that of ligustrazine with the same dosage. The invention widens the new application of the novel ligustrazine derivative, and has huge economic and social values.

Ligustrazine derivative, and preparation method and applications thereof

The invention provides a ligustrazine derivative, and a preparation method and applications thereof. The ligustrazine derivative is capable of treating IAA induced hypoxic injury, promoting neuron cell proliferation, promoting cell synapsis lengthening, and can be used for treating stroke and neurodegenerative diseases.

Reduction-sensitive nanomicelle and preparation method and application thereof

The invention discloses a preparation method and application of a reduction-sensitive nanomicelle, belongs to the technical field of nanomedicine, and particularly provides a preparation method of anamphiphilic prodrug self-assembled nanomicelle of methylpyrazine combined with paclitaxel or docetaxel and application of the nanomicelle in anti-tumor research. Through a nanoprecipitation approach and a dialysis approach, disulfide-bonded ligustrazine and a methylpyrazine analog thereof and the paclitaxel or the docetaxel are adopted for preparing prodrugs which are self-assembled into the nanomicelle, the operation is easy and convenient to implement, the particle size is small and uniform, the drug loading amount is high, and the nanomicelle can respond to a tumor microreduction environment, so that the tumor selectivity of the paclitaxel is improved, the effect of targeted treatment of tumors is achieved, the enrichment of drug concentration at tumor sites is improved, and the nanomicelle achieves good synergism and toxicity reduction effects in in-vivo and in-vitro anti-tumor application.