2298-16-0Relevant academic research and scientific papers
Optical Control of the GTP Affinity of K-Ras(G12C) by a Photoswitchable Inhibitor
Ge, Zhihua,Yang, Zhuojin,Liang, Jingshi,Dong, Duoling,Zhu, Mingyan
, p. 2916 - 2920 (2019/11/03)
Photocontrol of protein activity is an emerging field in biomedicine. For optical control of a mutant small GTPase K-Ras(G12C), we developed small-molecule inhibitors with photoswitchable efficacy, where one configuration binds the target protein and exer
A novel procedure to synthesize 3-chloro-1-(4a,10b-diazaphenanthrene-2-yl)- 4-phenyl azetidin-2-ones and exploration of their anti-inflammatory activity
Sharma, Manisha,Maheshwari, Arti,Bindal, Nitin
, p. E116-E120 (2013/06/04)
Some new derivatives of 3-chloro-1-(4a,10b-diazaphenanthrene-2-yl)-4-phenyl azetidin-2-one were synthesized through the reaction of N-{4-[phenyldiazenyl] phenyl}-N-[phenyl methylene] amine with 4-[phenyldiazenyl] aniline. The resulting 3-chloro-4-phenyl-1-{4-[phenyldiazenyl] phenyl} azetidin-2-one intermediate in benzene was irradiated in a Pyrex vessel with 350 nm UV light in a photochemical reactor to give the desired derivatives (4a-j). Structures of the new compounds were verified on the basis of spectral and elemental methods of analyses. Nine of the prepared compounds were tested for their anti-inflammatory effects; most of these compounds showed potent and significant results compared with indomethacin.
