229955-70-8Relevant academic research and scientific papers
Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation
Yoshida, Suguru,Yano, Takahisa,Misawa, Yoshihiro,Sugimura, Yasuyuki,Igawa, Kazunobu,Shimizu, Shigeomi,Tomooka, Katsuhiko,Hosoya, Takamitsu
supporting information, p. 14071 - 14074 (2015/11/25)
A novel method for preparing a diverse range of o-sulfanylanilines is described. Direct thioamination of arynes with sulfilimines gives o-sulfanylanilines, involving C-N and C-S bond formations and migratory N-arylation.
A practical approach to N-(trifluoroacetyl)sulfilimines
Gries, J?rg,Krüger, Jochen
supporting information, p. 1831 - 1834 (2014/08/18)
A new, simple method for the synthesis of N-(trifluoroacetyl)-protected sulfilimines from sulfides by a transition-metal-free, one-pot protocol is presented. The salient features of this process include the use of low-cost 1,3-dibromo-5,5-dimethylhydantoin, mild reaction conditions, and a broad substrate scope. The safety and robustness of the method has also been demonstrated by operations on a kilogram scale. In addition, a chiral resolution of a corresponding sulfoximine was achieved on a large scale. Georg Thieme Verlag Stuttgart. New York.
PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION
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Paragraph 0083, (2013/09/26)
The invention relates to a novel process for the preparation of pan-CDK inhibitors of the formula (I), and intermediates of the preparation.
