59236-38-3

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-4-METHYLBENZALDEHYDE is used as a key intermediate for the synthesis of various pharmaceuticals. Its versatile reactivity allows it to be a component in the development of a wide range of medicinal compounds, contributing to the advancement of healthcare and medicine.
Used in Dye Industry:
In the dye industry, 2-AMINO-4-METHYLBENZALDEHYDE is utilized as a crucial intermediate for the production of different types of dyes. Its role in dye synthesis is essential for creating a broad spectrum of colors used in various applications, including textiles, printing, and other industrial processes.
Used in Organic Compounds Synthesis:
2-AMINO-4-METHYLBENZALDEHYDE is also used as an intermediate in the synthesis of various organic compounds. Its presence in the chemical reactions facilitates the creation of a diverse array of organic molecules, which are integral to numerous chemical and material applications.
Used in Chemical Research:
2-AMINO-4-METHYLBENZALDEHYDE is employed as a valuable reagent in chemical research. Its wide range of applications and reactivity make it an indispensable tool for scientists and researchers working on new chemical discoveries and innovations.

Upstream product

• 20357-22-6 2-nitro-4-methylbenzaldehyde 
• 22996-24-3 (4-methyl 2-nitro-phenyl)-methanol 
• 27329-27-7 4-methyl-2-nitrobenzoic acid 
• 81335-87-7 (2-amino-4-methylphenyl)methanol 
• 2305-36-4 4-methylanthranilic acid 
• 89-62-3 4-methyl-2-nitroaniline 

Relevant academic research and scientific papers

Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes

We report an unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asymmetric C?C bonds

Chiral Phosphoric-Acid-Catalyzed Cascade Prins Cyclization

Asymmetric Prins cyclization of in situ generated quinone methides and o-aminobenzaldehyde has been developed with chiral phosphoric acid as an efficient catalyst. This unconventional method provides a facile access to diverse functionalized trans-fused pyrano-/furo-tetrahydroquinoline derivatives in excellent yield and with excellent diastereo- and enantioselectivities (up to 99% yield and 99% ee). Mechanistic studies suggested that the three adjacent tertiary stereocenters were constructed through the sequential formation of C-O, C-C, and C-N bonds.

Easy Access to Quinolin-2(1 H)-ones via a One-Pot Tandem Oxa-Michael-Aldol Sequence

An efficient strategy for the synthesis of a variety of quinolin-2(1 H)-one derivatives has been developed. The reaction proceeded from cinnamide derivatives via a tandem reaction in the presence of NaOH to afford the corresponding 2- quinolin-2(1 H)-one derivatives in good to excellent yields.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring a substituted camptothecin analogues. Structure-activity correlations

Nineteen racemic ring A substituted analogues of the antitumor agent 20(S)-camptothecin were prepared by total synthesis and evaluated for in vitro cytotoxic activity against KB cell culture and in vivo antileukemic activity against L1210. These compounds bore a wide variety of substitutents at C11 designed to confer upon the ring system a broad range of combinations of electronic, steric, and lipophilic effects. A few C10-substituted derivatives as well as C10,C11-disubstituted analogues prepared as part of a concurrent study have also been included for general comparison. With the notable exception of the cyano derivative, the 11-substituted compounds displayed only modest in vitro and in vivo activities, and there was a remarkable insensitivity toward the nature of the substituent. In contrast, the 9- and 10-substituted compounds exhibited a considerably higher level of dose potency and activity both in vitro and in vitro.