2300-11-0

Usage

Uses

Used in Pharmaceutical Industry:
(5beta,8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-ol is used as an anti-inflammatory agent for its ability to inhibit various human neutrophil functions. This makes it a promising candidate for the treatment of inflammatory diseases such as rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive pulmonary disease, asthma, and other conditions characterized by excessive inflammation.
Used in Research and Development:
In the field of research and development, (5beta,8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-ol serves as a valuable compound for studying the underlying mechanisms of inflammation and the role of human neutrophils in various disease processes. Its unique structure and biological activities can provide insights into the development of novel therapeutic strategies for managing inflammation-related disorders.
Used in Drug Discovery:
(5beta,8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-ol can be utilized in drug discovery efforts to identify new lead compounds or optimize existing ones for the treatment of inflammatory diseases. Its anti-inflammatory properties and interaction with human neutrophils make it a valuable starting point for the design and synthesis of more potent and selective pharmaceutical agents.

Upstream product

• 150-96-9 3-hydroxy-3-methylpentanoic acid 
• 469-85-2 kaurene 

Downstream Products

• 43161-39-3 (+/-)-16β-Kauran-17,19-diol 
• 10244-92-5 (+/-)-16β-Kauran-17.19-disaeure 
• 10179-10-9 ent-15α-hydroxykaurene 
• 149249-32-1 neotripterifordin 
• 139122-81-9 tripterifordin 
• 1426659-79-1 ent-kaur-16-en-19-ol 19-O-cinnamate 
• 5524-25-4 kaurenoic acid methyl ester 
• 5095-09-0 kaurenoic acid 
• 5282-24-6 ent-kaur-16-en-19-al 

Relevant academic research and scientific papers

BIOSYNTHESIS OF GIBBERELLIN A12-ALDEHYDE, GIBBERELLIN A12 AND THEIR KAURENOID PRECURSORS FROM MEVALONIC ACID IN A CELL-FREE SYSTEM FROM IMMATURE SEED OF PHASEOLUS COCCINEUS

A cell-free system capable of gibberellin (GA) biosynthesis has been prepared from immature seed of Phaseolus coccineus.This system converted mevalonic acid (MVA) to ent-kaurene, ent-kaurenoic acid, ent-kauradienoic acid, ent-7α-hydroxykaurenoic acid, ent-6α,7α-dihydroxykaurenoic acid, GA12-aldehyde and GA12. ent-Kaurene was converted to ent-kaurenol, ent-kaurenal, ent-kaurenoic acid and ent-7α-hydroxykaurenoic acid.All identifications were by GC/MC.The pathway from MVA to GA12-aldehyde in this species thus appears to be the same as that found in cell-free preparations derived from immature seed of other species.Key Word Index-Phaseolus coccineus; Leguminosae; runner bean; seed development; biosynthesis; cell-free system; HPLC; GC/MC; gibberellin.

KAURENOLIDE BIOSYNTHESIS IN A CELL-FREE SYSTEM FROM CUCURBITA MAXIMA SEEDS

A new product obtained by incubation of -mevalonic acid with a cell-free system from Cucurbita maxima endosperm was identified by GC-MS as ent-kaura-6,16-dien-19-oic acid.When this compound was reincubated with the microsomal fraction it was converted to 7β-hydroxykaurenolide and hence to 7β,12α-dihydroxykaurenolide.The dienoic acid was also obtained by incubation of ent-kaurene, ent-kaurenol, ent-kaurenal and ent-kaurenoic acid, but not ent-7α-hydroxykaurenoic acid, with the microsomal fraction.Thus, in the C. maxima cell-free system, the kaurenolides are formed by a pathway which branches from the GA pathway at ent-kaurenoic acid and proceeds via the dienoic acid.Key Word Index- Cucurbita maxima; Cucurbitaceae; biosynthesis; cell-free system; kaurenolides; gibberellins; ent-kaura-6,16-dien-19-oic acid.