23010-33-5

Upstream product

• 3795-78-6 2-ethylsulfanyl-benzoic acid methyl ester 
• 4892-02-8 Methyl thiosalicylate 
• 21101-79-1 2-ethylsulfanylbenzoic acid 
• 37527-69-8 (2-ethylsulfanyl-phenyl)-methanol 

Downstream Products

• 23121-10-0 1-chloromethyl-2-ethanesulfonyl-benzene 
• 1352128-46-1 8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]-pyrimidin-7-one 
• 1352128-14-3 8-(2-ethanesulfonyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-48-3 6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-49-4 6-bromo-8-(2-ethanesulfonylbenzyl)-2-methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-50-7 6-bromo-8-(2-ethanesulfonylbenzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-17-6 8-(2-ethanesulfonylbenzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-6-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 37527-74-5 2-Ethylthiophenylessigsaeure 
• 37527-76-7 (2-ethylsulfanyl-phenyl)-acetic acid methyl ester 
• 37527-80-3 (2-Ethanesulfinyl-phenyl)-acetic acid methyl ester 
• 37527-72-3 2-Ethylthiobenzylcyanid 

Relevant academic research and scientific papers

Synthesis of 2,3-dihydrobenzo[b]thiophen-3-amine 1,1-dioxide derivatives via lda-mediated cyclization of o-(alkylsulfonyl)benzyl azides with denitrogenation

A new and efficient method for the synthesis of 2,3-dihydrobenzo[b]thiophen-3-amine 1,1-dioxide derivatives has been developed. Thus, treatment of o-(alkylsulfonyl)benzyl azides, which are readily obtainable from commercially available starting materials

PAK INHIBITORS FOR THE TREATMENT OF CANCER

Provided herein are methods of utilizing PAK inhibitors for the treatment of cancer. Further provided herein are compounds and formulations utilized for the treatment of cancer.

8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS

Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders.

Addition Reactions of Benzothiophen. Part 3. Addition and Ring-opening Reactions with Phenolic Ethers

In the presence of aluminium chloride, anisole, phenetole, diphenyl ether, and (methylthio)benzene are added rapidly across the 2,3-bond in benzothiophen to give, inter alia, a mixture of 2- and 3-(p-substituted aryl)-2,3-dihydrobenzothiophens (3) and (4).Contrary to expectation, the 2-isomer predominates in all cases, and the addition is irreversible.Reaction with anisole also leads to a novel ring-opened product, viz. (E)-4-methoxy-2'-methylthiostilbene (9a), which was synthesised unambigiuously.It is believed that benzothiophen is S-methylated by PhOMe-AlCl3 in a 'push-pull' reaction, and that the resulting positive charge is delocalised into the ring, thus allowing the 2-position to participate in electrophilic attack on a second molecule of anisole.The resulting quadrivalent sulphur intermediate achieves stabilisation by means of a rapid ring-opening reaction.Other aromatic methyl ethers give analogous products, but phenetole diphenyl ether, and (methylthio)benzene do not promote ring-opening.The ring-opening reaction is aided by the addition of MeBr- or EtBr-AlCl3; even phenetole will then undergo ring-opening.Under these conditions the S-alkyl group in the ring-opened product comes from the starting ether, and not from the added MeBr or EtBr.