37527-69-8

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 4892-02-8 Methyl thiosalicylate 
• 3795-78-6 2-ethylsulfanyl-benzoic acid methyl ester 
• 53606-33-0 2-(ethylsulfanyl)benzenecarbaldehyde 
• 4521-31-7 o-hydroxymethyl thiophenol 
• 21101-79-1 2-ethylsulfanylbenzoic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 23121-10-0 1-chloromethyl-2-ethanesulfonyl-benzene 
• 1352128-46-1 8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]-pyrimidin-7-one 
• 1352128-14-3 8-(2-ethanesulfonyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-48-3 6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-49-4 6-bromo-8-(2-ethanesulfonylbenzyl)-2-methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-50-7 6-bromo-8-(2-ethanesulfonylbenzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352128-17-6 8-(2-ethanesulfonylbenzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-6-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 37527-74-5 2-Ethylthiophenylessigsaeure 
• 37527-72-3 2-Ethylthiobenzylcyanid 
• 37527-76-7 (2-ethylsulfanyl-phenyl)-acetic acid methyl ester 
• 37527-80-3 (2-Ethanesulfinyl-phenyl)-acetic acid methyl ester 
• 498534-34-2 2-(2'-ethylsulfonylbenzyl)-1,10-phenanthroline 
• 498534-32-0 2-(2'-ethylthiobenzyl)-1,10-phenanthroline 
• 498534-36-4 (2-ethylthio)benzyl bromide 

Relevant academic research and scientific papers

Three-Dimensional Heterocycles by Iron-Catalyzed Ring-Closing Sulfoxide Imidation

A general and atom-economical method for the synthesis of cyclic sulfoximines by intramolecular imidations of azido-containing sulfoxides using a commercially available FeII phthalocyanine (FeIIPc) as catalyst has been developed. The method conveys a broad functional group tolerance and the resulting three-dimensional heterocycles can be modified by cross-coupling reactions.

PAK INHIBITORS FOR THE TREATMENT OF CANCER

Provided herein are methods of utilizing PAK inhibitors for the treatment of cancer. Further provided herein are compounds and formulations utilized for the treatment of cancer.

8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS

Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders.

Synthesis of 2-benzyl-1,10-phenanthrolines substituted by sulfoxide or sulfone groups as potential photochromic compounds

New 2-benzyl-1,10-phenanthrolines, substituted at the 2′ position by electron-withdrawing groups, were synthesized through nucleophilic substitution involving 2-chloro-1,10-phenanthroline and substituted benzyllithiums, respectively. The expected reversible photoinduced proton transfer reaction of such compounds were studied.

Pyrazinone thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein A is

Control of the orientation of the aldehyde group in 2-(alkylthio)benzaldehydes by the directional lone-pair on sulfur

The (1)H nmr spectral parameters for 2-alkylthio derivatives benzaldehyde (alkyl = CH3, CH2CH3, CH(CH3)2, C(CH3)3) are used to show that the O-syn conformation of the aldehyde group decreases from 40percent for the methyl to zero for the tert-butyl compound in CCl4 solution at about 300 K.It appears that the alkylthio groups twist out of the benzene plane to the same extent as in the alkyl phenyl sulfides and that is the concomitant approaches of the 3p lone-pairs on sulfur into the ring plane which, by repulsive interactions with the C=O bond, determine the conformations of the aldehyde group.The spectral parameters display interesting changesas the size of the alkyl group increases.For example, the chemical shift of the aldehydic proton is larger than that reported for any other benzaldehyde derivative in CCl4 solution.

Intramolecular Reactions of o-Alkoxy- and o-Alkylthio-benzyl Radicals

We report new gas-phase reactions of o-substituted benzyl radicals produced by flash vacuum pyrolysis of 2,3-dihydro-1,3,2-benzoxazaphosph(V)oles (4)-(6), dibenzyl sulphone (8), and dibenzyl oxalates (9)-(11).Both o-ethoxy- and o-methoxy-benzyl radicals rearrange to o-tolualdehyde via intramolecular hydrogen transfer, as shown by experiments using 2-methoxybenzyl radicals. o-Methylthiobenzyl radicals do not give the corresponding thioaldehyde, but produce a mixture of benzocyclobutene and isomeric dihydrobenzothiophens by novel rearrangement reactions. o-Ethylthio- and o-propylthio-benzyl radicals give o-methylstyrene and o-propenyltoluenes respectively as major products.