23012-10-4

Basic information

• Product Name: OXAZOLE, 2-METHYL-
• Synonyms: OXAZOLE, 2-METHYL-;2-Methyloxazole;2-Methyloxazole HCl;-Methyloxazole
• CAS NO: 23012-10-4
• Molecular Formula: C₄H₅NO
• Molecular Weight: 83.0886
• Mol File: 23012-10-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 133.5-135.5 °C
• Boiling Point: 82.277 °C at 760 mmHg
• Flash Point: 17.809 °C
• Appearance: /
• Density: 1.017 g/cm³
• Storage Temp.: 2-8°C
• PKA: 2.13±0.10(Predicted)
• CAS DataBase Reference: OXAZOLE, 2-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: OXAZOLE, 2-METHYL-(23012-10-4)
• EPA Substance Registry System: OXAZOLE, 2-METHYL-(23012-10-4)

Safety Data

• Hazardous Substances Data: 23012-10-4(Hazardous Substances Data)

Usage

General Description

2-Methyl-oxazole is a heterocyclic compound with the formula C4H5NO. It is a five-membered aromatic ring with one nitrogen and one oxygen atom. 2-Methyl-oxazole is a colorless liquid with a slightly sweet odor, and it is used as a building block in organic synthesis and pharmaceutical manufacturing. It is also a component of some natural products and has been found to exhibit antimicrobial and anti-inflammatory properties. 2-Methyl-oxazole is considered to be non-toxic, but it should be handled in a well-ventilated area and precautions should be taken to avoid inhalation or skin contact.

Upstream product

• 23012-17-1 2-methyl-1,3-oxazol-4-carboxylic acid 

Downstream Products

• 1428761-22-1 methyl 2-(2-chloro-4-(2-methyloxazol-5-yl)phenyl)acetate 
• 275377-93-0 2-[(diphenylphosphanyl)-methyl]-4,5-dihydrooxazole 

Relevant articles and documents

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks

An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.

ANTIBACTERIAL AGENTS

The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.