23012-10-4

Usage

Uses

Used in Organic Synthesis:
Oxazole, 2-methylis used as a building block in organic synthesis for its ability to contribute to the formation of complex molecular structures, enhancing the development of new chemical compounds.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, Oxazole, 2-methylserves as a key intermediate in the synthesis of various drugs, leveraging its unique chemical properties to improve medicinal efficacy and safety.
Used in Natural Products:
Oxazole, 2-methylis found as a component in some natural products, contributing to their overall properties and potential applications in various fields.
Used in Antimicrobial Applications:
Oxazole, 2-methylis utilized for its antimicrobial properties, serving as an agent to combat microbial growth in different settings, thereby preserving the quality and safety of various products.
Used in Anti-inflammatory Applications:
Leveraging its anti-inflammatory properties, Oxazole, 2-methylis applied in treatments or products aimed at reducing inflammation, providing relief in conditions where such effects are beneficial.

Upstream product

• 23012-17-1 2-methyl-1,3-oxazol-4-carboxylic acid 

Downstream Products

• 275377-93-0 2-[(diphenylphosphanyl)-methyl]-4,5-dihydrooxazole 
• 1428761-22-1 methyl 2-(2-chloro-4-(2-methyloxazol-5-yl)phenyl)acetate 

Relevant academic research and scientific papers

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks

An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.

Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases

The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compounds, processes for making said compounds, and their use as medicaments for treatment and/or prevention of Aβ-related diseases.

ANTIBACTERIAL AGENTS

The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.

A Retro-Diels-Alder Approach to Oxazoles and Imidazoles

Heating N-acyl derivatives 4 of 3-endo-aminobicyclohept-5-en-2-endo-ol (3) at 185-195 deg C for 4-5 h provides oxazoles 1a-e in 49-88percent yields.The reaction proceeds via an initial dehydration to an oxazoline which undergoes retro-Diels-Alder reaction to provide the oxazole.Similarly, imidazoles 7a-f may be obtained in 40-79percent yields by heating imidazolines 6a-f to effect the cycloreversion.