23012-19-3

Basic information

• Product Name: 1-(4-Methyloxazol-5-yl)ethanone
• Synonyms: 1-(4-METHYLOXAZOL-5-YL)ETHANONE;5-Acetyl-4-methyloxazole;1-(4-Methyl-1,3-oxazol-5-yl)ethan-1-one;Ketone, Methyl 4-Methyl-5-oxazolyl
• CAS NO: 23012-19-3
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• Mol File: 23012-19-3.mol

Chemical Properties

• Melting Point: 15-15.5 °C(Solv: methanol (67-56-1))
• Boiling Point: 190.592 °C at 760 mmHg
• Flash Point: 69.068 °C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0.537mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: 2-8°C
• PKA: -1.14±0.14(Predicted)
• CAS DataBase Reference: 1-(4-Methyloxazol-5-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methyloxazol-5-yl)ethanone(23012-19-3)
• EPA Substance Registry System: 1-(4-Methyloxazol-5-yl)ethanone(23012-19-3)

Safety Data

• Hazardous Substances Data: 23012-19-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
1-(4-Methyloxazol-5-yl)ethanone is used as a building block for the synthesis of various other compounds, leveraging its unique chemical structure to facilitate the creation of novel organic molecules.
Used in Fragrance Industry:
1-(4-Methyloxazol-5-yl)ethanone is used as a fragrance ingredient, where it contributes to the aroma of certain perfumes and flavors, enhancing the sensory experience of these products.
Used in Pharmaceutical Industry:
1-(4-Methyloxazol-5-yl)ethanone is used as a starting material or intermediate in the development of pharmaceuticals, capitalizing on its chemical properties to create new drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
1-(4-Methyloxazol-5-yl)ethanone is used in the formulation of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness of these products in agricultural applications.

InChI:InChI=1/C6H7NO2/c1-4-6(5(2)8)9-3-7-4/h3H,1-2H3

Upstream product

• 77287-34-4 formamide 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 70345-38-9 5-hydroxy-4,6-dimethylpyridimine 
• 161531-34-6 5-(2-benzyloxy-1,1-dmethoxy)ethyl-4-methyloxazole 
• 161531-36-8 4-benzyloxymethyl-5-hydroxy-6-methylpyrimidine 
• 161531-35-7 5-(2-benzyloxyacetyl)-4-methyloxazole 
• 101708-13-8 5-hydroxy-4-hydroxymethyl-6-methylpyrimidine 

Relevant articles and documents

6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation

A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer activity of the compounds was evaluated using hepatocellular carcinoma (HCC) cell lines and a chick chorioallantoic membrane (CAM) tumour model. Compound 6O showed FGFR4 inhibitory activity over FGFR1 ? 3. Compared to the positive control BLU9931, compound 6O exhibited at least 8 times higher FGFR4 selectivity. Strong anti-proliferative activity of compound 6O was observed against Hep3B, an HCC cell line which was a much more sensitive cell line to BLU9931. In vivo anti-tumour activity of compound 6O against Hep3B-xenografted CAM tumour model was almost similar to BLU9931. Overall, compound 6O, a novel derivative of aminodimethylpyrimidinol, was a selective FGFR4 kinase inhibitor blocking HCC tumour growth.

Substituted pyrazolyl compounds and methods employing such compounds

This invention pertains to novel substituted pyrazolyl compounds useful as intravenous anesthetics represented by the Formula: STR1 including geometric and optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein: one of Y and Z is nitrogen, and the other is CH; R1 is hydrogen or lower-alkyl; R2 and R3 are selected from the group consisting of hydrogen, --CHO, lower-alkylcarbonyl, lower-alkoxy carbonyl, lower-alkylaminocarbonyl, lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkenyl, lower-alkylcarbonyloxymethyl, substituted and unsubstituted heterocyclic rings, and substituted or unsubstituted aryl groups, wherein the symbol * represents a carbon atom which may be asymmetric and at least one of R2 and R3 is other than hydrogen.