70345-38-9 Usage
Uses
Used in Pharmaceutical Industry:
5-Pyrimidinol, 4,6-dimethyl(6CI,9CI) is used as a key intermediate in the synthesis of various medications. Its unique structure and properties make it a valuable building block for the development of new pharmaceutical compounds, contributing to the advancement of medical treatments and therapies.
Used in Agricultural Industry:
In the agricultural sector, 5-Pyrimidinol, 4,6-dimethyl(6CI,9CI) serves as a crucial component in the production of agricultural chemicals. Its incorporation into these chemicals helps improve crop protection, yield, and overall agricultural productivity.
Overall, 5-Pyrimidinol, 4,6-dimethyl(6CI,9CI) is a versatile chemical compound with a wide range of applications in both the pharmaceutical and agricultural industries. Its unique properties and potential uses make it an essential component in the development and manufacturing of various products, contributing to the betterment of human health and agricultural practices.
Check Digit Verification of cas no
The CAS Registry Mumber 70345-38-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,4 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 70345-38:
(7*7)+(6*0)+(5*3)+(4*4)+(3*5)+(2*3)+(1*8)=109
109 % 10 = 9
So 70345-38-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O/c1-4-6(9)5(2)8-3-7-4/h3,9H,1-2H3
70345-38-9Relevant academic research and scientific papers
6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation
Awasthi, Bhuwan Prasad,Chaudhary, Chhabi Lal,Chaudhary, Prakash,Guragain, Diwakar,Jeong, Byeong-Seon,Kim, Jung-Ae,Lim, Dongchul,Park, Hee Dong
, p. 844 - 856 (2022/03/27)
A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer activity of the compounds was evaluated using hepatocellular carcinoma (HCC) cell lines and a chick chorioallantoic membrane (CAM) tumour model. Compound 6O showed FGFR4 inhibitory activity over FGFR1 ? 3. Compared to the positive control BLU9931, compound 6O exhibited at least 8 times higher FGFR4 selectivity. Strong anti-proliferative activity of compound 6O was observed against Hep3B, an HCC cell line which was a much more sensitive cell line to BLU9931. In vivo anti-tumour activity of compound 6O against Hep3B-xenografted CAM tumour model was almost similar to BLU9931. Overall, compound 6O, a novel derivative of aminodimethylpyrimidinol, was a selective FGFR4 kinase inhibitor blocking HCC tumour growth.
