23030-43-5

Usage

Derivative of

Resorcinol

Uses

a. Production of dyes
b. Pharmaceuticals
c. Industrial applications

Physical state

White to off-white crystalline solid

Solubility

Soluble in organic solvents

Application

a. Reagent in organic synthesis
b. Preparation of iodine-containing compounds
c. Precursor in advanced materials and pharmaceuticals

Potential use

Radiocontrast agent for medical imaging due to iodine content

InChI:InChI=1/C6H5IO2/c7-5-3-4(8)1-2-6(5)9/h1-3,8-9H

Upstream product

• 106-51-4 p-benzoquinone 
• 150-78-7 1,4-dimethoxybezene 
• 123-31-9 hydroquinone 
• 108-95-2 phenol 
• 626-02-8 3-Iodophenol 

Downstream Products

• 19012-99-8 6-hydroxy-2,2-dimethyl-2H-chromene 
• 18231-99-7 1,4-dihydroxy-2-(methylthio)benzene 
• 123-31-9 hydroquinone 
• 99208-50-1 10?(2,5?dihydroxyphenyl)?10H-9?oxa?10?phosphaphenanthrene?10?oxide 
• 1335242-39-1 (E)-6-fluoro-4-methoxy-2',3,5'-trihydroxystilbene 
• 1093198-97-0 (E)-2',3,4,5'-tetrahydroxystilbene 
• 1335242-40-4 (E)-4-methoxy-2',3,5'-trihydroxystilbene 
• 1335242-33-5 (E)-2',3,5'-trihydroxystilbene 
• 1093198-83-4 2-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,4-benzenediol 
• 1335242-37-9 (E)-2,2',5'-trihydroxystilbene 
• 7182-29-8 5-hydroxy-2-phenylbenzofuran 
• 1449510-36-4 (E)-2',5'-dihydroxy-3,4-dimethoxystilbene 
• 1449510-37-5 (E)-3,5-dimethoxy-4,2',5'-trihydroxystilbene 
• 1394048-08-8 (E)-3-methoxy-2',4,5'-trihydroxystilbene 

Relevant academic research and scientific papers

Enzyme-Catalysed Synthesis of Cyclohex-2-en-1-one cis-Diols from Substituted Phenols, Anilines and Derived 4-Hydroxycyclohex-2-en-1-ones

Toluene dioxygenase-catalysed cis-dihydroxylations of substituted aniline and phenol substrates, with a Pseudomonas putida UV4 mutant strain and an Escherichia coli pCL-4t recombinant strain, yielded identical arene cis-dihydrodiols, which were isolated as the preferred cyclohex-2-en-1-one cis-diol tautomers. These cis-diol metabolites were predicted by preliminary molecular docking studies, of anilines and phenols, at the active site of toluene dioxygenase. Further biotransformations of cyclohex-2-en-1-one cis-diol and hydroquinone metabolites, using Pseudomonas putida UV4 whole cells, were found to yield 4-hydroxycyclohex-2-en-1-ones as a new type of phenol bioproduct. Multistep pathways, involving ene reductase- and carbonyl reductase-catalysed reactions, were proposed to account for the production of 4-hydroxycyclohex-2-en-1-one metabolites. Evidence for the phenol hydrate tautomers of 4-hydroxycyclohex-2-en-1-one metabolites was shown by formation of the corresponding trimethylsilyl ether derivatives. (Figure presented.).

Isoquinolinium Dichromate and Chlorochromate as Efficient Catalysts for Oxidative Halogenation of Aromatic Compounds under Acid-Free Conditions

Isoquinolinium dichromate and isoquinolinium chlorochromate were found as efficient catalysts to trigger oxidative bromination and iodination of aromatic hydrocarbons with KBr/KI and KHSO4 under acid-free conditions. Reaction times reduced highly significantly under sonication, followed by corresponding mono bromo derivatives in very good yield with high regioselectivity.

C-substituted, 1H-azoles for amphoteric, solvent-less proton conductivity

Disclosed herein are the compounds shown below. Also disclosed are methods of making the compounds. R1=—O—; R2=any alkyl chain; R3=—CH3, —CN, —COOCH3, -tetrazole, -imidazole, or -triazole; R4=—H or —R5; R5=—H, -halogen, —C≡CH, or —C≡C—; n is a positive integer; and m is a positive integer.

C-SUBSTITUTED, 1H-AZOLES FOR AMPHOTERIC, SOLVENT-LESS PROTON CONDUCTIVITY

Disclosed herein are the compounds shown below. Also disclosed are methods of making the compounds. R1=—O—; R2=any alkyl chain; R3=—CH3, —CN, —COOCH3, -tetrazole, -imidazole, or -triazole; R4=—H or —R5; R5=—H, -halogen, —C≡CH, or —C≡C—; n is a positive integer; and m is a positive integer.

Selective iodination of some phenols, anilines and methoxyarenes by molecular iodine in the presence of 1-butyl-3-methylimidazolium hydrogen sulphate

A simple, mild and regioselective method for the iodination of some phenols, anilines and methoxyarenes by using molecular iodine in presence of 1-butyl-3-methylimidazolium hydrogen sulphate ([bmim]-HSO4) in acetonitrile as solvent is reported. One-pot synthesis, mild reaction conditions, short reaction times and excellent yields of the products are noteworthy.

Process for the iodination of aromatic compounds

The present invention relates to a process for the preparation of iodinated phenols; in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2,4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

A simple iodination protocol via in situ generated ICl using NaI/FeCl 3

A novel iodination of silyl-enol ethers using hitherto unexplored NaI/FeCl3 system is reported. The procedure has been extended to the iodination of aromatic and hetero aromatic compounds.