949922-62-7

Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE is used as an intermediate in the development and production of various types of drugs, including antifungal and antiparasitic agents. Its unique chemical structure allows for the synthesis of novel compounds with potential therapeutic effects.
Used in Agrochemical Industry:
TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE is utilized in the manufacturing of crop protection products and insecticides. Its ability to be incorporated into various chemical formulations makes it a valuable component in the development of effective pest control solutions.
Used in Chemical Research and Development:
TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE is considered a useful building block for the synthesis of diverse organic compounds. Its versatility and reactivity make it a valuable tool in chemical research and development, enabling the creation of new compounds with potential applications in various industries.

InChI:InChI=1/C12H16BrNO2S/c1-12(2,3)16-11(15)14-5-4-9-8(7-14)6-10(13)17-9/h6H,4-5,7H2,1-3H3

Upstream product

• 28783-41-7 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride 
• 226386-47-6 2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 230301-73-2 6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester 

Downstream Products

• 150322-43-3 prasugel 
• 150322-38-6 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one 
• 1333429-06-3 2-(N-morpholinyl)-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4.5.6.7-tetrahydro-thieno-[3,2-c]pyridine 
• 165947-48-8 5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid 
• 2246556-84-1 tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate 
• 165947-55-7 tert-butyl 2-(formyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate 
• 1613148-58-5 N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-3-(1-(2,5-difluorophenyl)ethoxy)pyridin-2-amine 
• 1613148-52-9 N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine 

Relevant academic research and scientific papers

Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors

A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors. Structure-activity relationship for this class of inhibitor resulted in the discovery of most potent compounds 15a and 15b that e

Significant Discovery of Tetrahydrothieno[3,2-c]pyridine-2-carboxamide Analogs as Potent P2Y12 Receptor Antagonists

A series of analogs containing tetrahydrothieno[3,2-c]pyridine-2-carboxamide as a building block with numerous alicyclic and aromatic amines were synthesized. All analogs were characterized by spectral analysis and evaluated for their in vitro antiplatelet activity. 4-Fluorophenyl amide derivatives (compounds 8–11) have been found to be most active in the series with respect to prasugrel and aspirin, a third generation antiplatelet agents (P2Y12 receptor antagonists). Docking study also manifested the admirable binding mode of in vitro active compounds 10 and 11 with the target protein. The results may provide a new perception for future pharmacophore with simple design strategy and avoid tedious synthesis of clopidogrel and prasugrel.

Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors

The nuclear protein poly(ADP-ribose) polymerases-1/2 (PARP-1/2) are involved in DNA repair damaged by endogenous or exogenous process. And PARP-1/2 inhibitors have been proved to be clinically efficacious for DNA repair deficient tumors in the past decade

Substituted oxazolidinone compounds and method and use thereof

The invention provides a substituted oxazolidinone compound represented by a formula (I) shown in specifications, or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof. The compound i

A PROCESS FOR MAKING PRASUGREL

The present invention relates to A compound of general Formula (A), and/or acid addition salts thereof, wherein R is a hydrogen atom or a nitrogen-protecting group or an alpha- cyclopropylcarbonyl-2-fluorobenzyl group and R1,R2 is independently a C1-C10 alkyl group, optionally having one or more carbons substituted by a hydroxy group, or R1,R2 together with the bridging nitrogen may form a ring comprising from 3 to 10 carbon atoms, optionally also comprising another nitrogen, oxygen or sulfur atom in the ring and/or a nitrogen-, oxygen-, or sulfur-comprising substituent on the ring, to a process of making and use in making prasugrel.

Inhibitors of farnesyl-protein transferase

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent